{"id":"W4210538253","doi":"10.3389/fcimb.2021.709258","title":"Leishmania Exosomes/Extracellular Vesicles Containing GP63 Are Essential for Enhance Cutaneous Leishmaniasis Development Upon Co-Inoculation of Leishmania amazonensis and Its Exosomes","year":2022,"lang":"en","type":"article","venue":"Frontiers in Cellular and Infection Microbiology","topic":"Extracellular vesicles in disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":51,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; McGill University Health Centre","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research","keywords":"Leishmania; Microvesicles; Biology; Cutaneous leishmaniasis; Vesicle; Extracellular vesicle; Leishmaniasis; Virulence; Virulence factor; Cell biology; Leishmania major; Leishmania tropica; Amastigote; Microbiology; Immunology; Parasite hosting; Biochemistry; microRNA; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001331164,0.0001892814,0.0001934515,0.0001233759,0.0001105433,0.0003041696,0.00006896027,0.0002129395,0.0006417707],"category_scores_gemma":[0.0001702123,0.00008761606,0.0002322106,0.0000764705,0.0001338255,0.0002783598,0.000269352,0.0003110141,0.0001497633],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001051412,"about_ca_system_score_gemma":0.0000836146,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001930158,"about_ca_topic_score_gemma":0.00023352,"domain_scores_codex":[0.9998541,0.00003016507,0.00001593093,0.00002729067,0.0000414129,0.0000310697],"domain_scores_gemma":[0.99993,0.000009684754,0.00002121545,0.000008351582,0.00001545357,0.00001522637],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006688513,0.00001185,0.0004166067,0.00004373155,0.0000045097,0.00008850266,0.00002102722,0.00001692366,0.9986531,0.00003912348,0.00001164589,0.0006260926],"study_design_scores_gemma":[0.00001704998,0.0004404178,0.02440548,0.00002434509,0.00003817408,0.001137246,0.0001607352,0.001060936,0.9692252,0.000101144,0.003382271,0.000007067624],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9968657,0.0008160195,0.001514739,0.0000509085,0.00001906111,0.00002713341,0.0002131302,0.00002275766,0.0004706405],"genre_scores_gemma":[0.9977109,0.0003677811,0.0008948873,0.00002444566,0.000005204018,0.00002076133,0.0002674008,0.00000866229,0.0006998996],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006417707,"threshold_uncertainty_score":0.0021469,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007381983385888801,"score_gpt":0.2291609049239997,"score_spread":0.2217789215381109,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}