{"id":"W4210538253","doi":"10.3389/fcimb.2021.709258","title":"Leishmania Exosomes/Extracellular Vesicles Containing GP63 Are Essential for Enhance Cutaneous Leishmaniasis Development Upon Co-Inoculation of Leishmania amazonensis and Its Exosomes","year":2022,"lang":"en","type":"article","venue":"Frontiers in Cellular and Infection Microbiology","topic":"Extracellular vesicles in disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":51,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; McGill University Health Centre","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research","keywords":"Leishmania; Microvesicles; Biology; Cutaneous leishmaniasis; Vesicle; Extracellular vesicle; Leishmaniasis; Virulence; Virulence factor; Cell biology; Leishmania major; Leishmania tropica; Amastigote; Microbiology; Immunology; Parasite hosting; Biochemistry; microRNA; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0004544277,0.0003345334,0.0004923026,0.0002707268,0.0003857732,0.00003151631,0.000209937,0.0002625717,0.00003360384],"category_scores_gemma":[0.0001066809,0.0004040925,0.0001267899,0.0001582804,0.000143352,0.00002592004,0.0002981709,0.0002218279,0.000001380999],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001048921,"about_ca_system_score_gemma":0.0001082978,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000263619,"about_ca_topic_score_gemma":0.00004607193,"domain_scores_codex":[0.9977406,0.0002845348,0.0006426949,0.0007921909,0.0001057328,0.0004341978],"domain_scores_gemma":[0.9989873,0.00004202209,0.0004317031,0.0003272643,0.0001136394,0.0000981062],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004759671,0.0001934152,0.05807766,0.0001761404,0.0001446257,0.00002097045,0.0002605353,0.0003887739,0.9370222,0.00006149868,0.0006411501,0.002537057],"study_design_scores_gemma":[0.001601692,0.0005387029,0.003563622,0.00003444962,0.00008168526,0.0001700774,0.000540528,0.0007455283,0.9642982,0.0001306716,0.02777182,0.0005229659],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9716989,0.01305079,0.01369357,0.00005371221,0.0006386173,0.000701243,0.0001094064,0.00002580164,0.0000280002],"genre_scores_gemma":[0.9952063,0.0005913111,0.002795712,0.00006285897,0.0001145175,0.0001355991,0.0007972548,0.0000533013,0.0002431526],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.05451404,"threshold_uncertainty_score":0.9998411,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007381983385888801,"score_gpt":0.2291609049239997,"score_spread":0.2217789215381109,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}