{"id":"W4210539884","doi":"10.1172/jci152930","title":"Metronidazole treatment rapidly reduces genital inflammation through effects on bacterial vaginosis–associated bacteria rather than lactobacilli","year":2022,"lang":"en","type":"article","venue":"Journal of Clinical Investigation","topic":"Reproductive tract infections research","field":"Immunology and Microbiology","cited_by":46,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre for Global Health Research; Toronto General Hospital; University Health Network; University of Toronto","funders":"University of Toronto; National Institutes of Health; King's College London; Canadian Institutes of Health Research; National Institute of Allergy and Infectious Diseases; Ontario HIV Treatment Network","keywords":"Lactobacillus crispatus; Bacterial vaginosis; Lactobacillus; Metronidazole; Gardnerella vaginalis; Immune system; Proinflammatory cytokine; Lactobacillus gasseri; Inflammation","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008202716,0.0005097368,0.001485091,0.0002297294,0.0001947634,0.0006894722,0.0004660579,0.0009375383,0.008236807],"category_scores_gemma":[0.001560752,0.0002622568,0.0007877871,0.0002573316,0.0003366041,0.0004934744,0.0002015352,0.001216714,0.0004261254],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004011557,"about_ca_system_score_gemma":0.0006640254,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005215306,"about_ca_topic_score_gemma":0.001583231,"domain_scores_codex":[0.9995709,0.0002151472,0.00004359045,0.00005953655,0.00004380515,0.00006692323],"domain_scores_gemma":[0.9995462,0.0001351091,0.000167373,0.00002676454,0.00004461992,0.00007983757],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.7298981,0.01059488,0.002955285,0.02026531,0.002647744,0.0001742555,0.0001361194,0.0005599656,0.05157891,0.0005748863,0.006341101,0.1742735],"study_design_scores_gemma":[0.7522362,0.1995884,0.0227638,0.001954249,0.002072159,0.0002531623,0.0001426521,0.000838809,0.009129433,0.000505045,0.01047016,0.00004592962],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9070019,0.07721104,0.001330237,0.002380048,0.001156062,0.004452677,0.002211411,0.0001719438,0.004084697],"genre_scores_gemma":[0.971639,0.01658773,0.002498988,0.001344831,0.0005141302,0.00341699,0.0007945758,0.00002551848,0.003178185],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.008236807,"threshold_uncertainty_score":0.02755481,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07097287300880298,"score_gpt":0.3653351124324978,"score_spread":0.2943622394236948,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}