{"id":"W4210539884","doi":"10.1172/jci152930","title":"Metronidazole treatment rapidly reduces genital inflammation through effects on bacterial vaginosis–associated bacteria rather than lactobacilli","year":2022,"lang":"en","type":"article","venue":"Journal of Clinical Investigation","topic":"Reproductive tract infections research","field":"Immunology and Microbiology","cited_by":46,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre for Global Health Research; Toronto General Hospital; University Health Network; University of Toronto","funders":"University of Toronto; National Institutes of Health; King's College London; Canadian Institutes of Health Research; National Institute of Allergy and Infectious Diseases; Ontario HIV Treatment Network","keywords":"Lactobacillus crispatus; Bacterial vaginosis; Lactobacillus; Metronidazole; Gardnerella vaginalis; Immune system; Proinflammatory cytokine; Lactobacillus gasseri; Inflammation","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002253716,0.000204449,0.0005633702,0.000214704,0.0003717785,0.00005227275,0.00021965,0.0002100151,0.0006087186],"category_scores_gemma":[0.002585625,0.0001634488,0.0003469879,0.0003133723,0.0002304881,0.0004571668,0.00006255686,0.0008960746,0.000136965],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004636285,"about_ca_system_score_gemma":0.0003421124,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004475467,"about_ca_topic_score_gemma":0.000008140964,"domain_scores_codex":[0.9947913,0.003180774,0.001241931,0.0003019154,0.0002078377,0.0002761926],"domain_scores_gemma":[0.9966784,0.001449085,0.001246706,0.0002532103,0.0003098823,0.00006274748],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001409141,0.0008727068,0.02166953,0.000008855437,0.001080327,0.00001266267,0.0007969085,0.0001501126,0.9528894,0.0002207967,0.002222421,0.01866712],"study_design_scores_gemma":[0.004368178,0.007537462,0.2211462,0.00003885516,0.0001778328,0.00006262682,0.0001738694,0.000007268435,0.7453122,0.001220304,0.01975626,0.0001989701],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9933399,0.0001749814,0.00002064702,0.001619436,0.004099895,0.0004046746,0.00002381676,0.00004271489,0.0002739575],"genre_scores_gemma":[0.9981842,0.00009343884,0.0001518211,0.00008137932,0.0008097267,0.00004798331,0.000150468,0.00002307332,0.0004579323],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2075772,"threshold_uncertainty_score":0.6665249,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07097287300880298,"score_gpt":0.3653351124324978,"score_spread":0.2943622394236948,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}