{"id":"W4210547181","doi":"10.1093/hmg/ddac030","title":"Genome-wide interaction analysis identified low-frequency variants with sex disparity in lung cancer risk","year":2022,"lang":"en","type":"article","venue":"Human Molecular Genetics","topic":"Genetic Associations and Epidemiology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"Sinai Health System; Lunenfeld-Tanenbaum Research Institute; University of Toronto; University Health Network; Public Health Ontario; University of British Columbia; Princess Margaret Cancer Centre; Université Laval; Institut universitaire de cardiologie et de pneumologie de Québec","funders":"Common Fund; National Institute of Environmental Health Sciences; National Institute on Drug Abuse; Division of Cancer Epidemiology and Genetics, National Cancer Institute; National Institute of Neurological Disorders and Stroke; National Heart, Lung, and Blood Institute; National Institute of Mental Health; NIH Office of the Director; National Cancer Institute; U.S. Department of Health and Human Services; National Institutes of Health; Cancer Prevention and Research Institute of Texas; National Human Genome Research Institute; World Health Organization","keywords":"Lung cancer; Biology; Genome-wide association study; Odds ratio; Genetic association; Genotype; Cancer; Sexual dimorphism; Genetics; Allele frequency; Oncology; Internal medicine; Single-nucleotide polymorphism; Gene; Endocrinology; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007632341,0.0005493632,0.0006174151,0.0008732553,0.0004204273,0.000585859,0.0003630903,0.0004988922,0.003665787],"category_scores_gemma":[0.001446661,0.0001673124,0.002220098,0.0009900857,0.0002849045,0.0001536922,0.0004372825,0.0007206193,0.0002102536],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001560808,"about_ca_system_score_gemma":0.0003947193,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002722733,"about_ca_topic_score_gemma":0.004905059,"domain_scores_codex":[0.998948,0.0002868631,0.0001006747,0.0003880954,0.0001168679,0.0001595742],"domain_scores_gemma":[0.999063,0.0004862106,0.0001627742,0.0001051421,0.00005277363,0.0001301958],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001945475,0.00009888005,0.9308237,0.0001111111,0.0036298,0.00194996,0.0002410132,0.0003056334,0.04780447,0.0004325432,0.0004677425,0.01218972],"study_design_scores_gemma":[0.00004888635,0.0001786133,0.9931625,0.000007822733,0.001230789,0.001019431,0.00008076862,0.001231816,0.001981025,0.0003536172,0.0006907246,0.00001405507],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9957927,0.0008067932,0.00197816,0.000134262,0.00003552843,0.00001287602,0.0007248799,0.00003915328,0.0004755016],"genre_scores_gemma":[0.9985103,0.00008651643,0.0006548823,0.00005022926,0.00001723574,0.0000105394,0.0003523194,0.00001395975,0.00030383],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003665787,"threshold_uncertainty_score":0.01226324,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008948507421887861,"score_gpt":0.2784707377927614,"score_spread":0.2695222303708735,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}