{"id":"W4210547189","doi":"10.1093/emph/eoac003","title":"Immune cell type and DNA methylation vary with reproductive status in women: possible pathways for costs of reproduction","year":2022,"lang":"en","type":"article","venue":"Evolution Medicine and Public Health","topic":"Reproductive System and Pregnancy","field":"Immunology and Microbiology","cited_by":18,"is_retracted":false,"has_abstract":true,"ca_institutions":"BC Children's Hospital; University of British Columbia; Canadian Institute for Advanced Research; University of Manitoba; Children's Hospital Research Institute of Manitoba","funders":"National Heart, Lung, and Blood Institute; Natural Sciences and Engineering Research Council of Canada; Canadian Institute for Advanced Research; National Science Foundation","keywords":"DNA methylation; Reproduction; Immune system; Biology; DNA; Epigenetics; Physiology; Medicine; Immunology; Bioinformatics; Genetics; Gene; Gene expression","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003440364,0.0001209264,0.000378711,0.0003069044,0.0002984205,0.000003575665,0.00005226794,0.0000560355,0.00007493488],"category_scores_gemma":[0.000458543,0.00009865165,0.00001250472,0.0006381653,0.0001852038,0.0001623805,0.00004611168,0.0002114237,9.038114e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003423583,"about_ca_system_score_gemma":0.0005304489,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001268507,"about_ca_topic_score_gemma":0.00001948728,"domain_scores_codex":[0.9977999,0.0007089584,0.0004555697,0.0005832292,0.00007550405,0.0003768849],"domain_scores_gemma":[0.9988859,0.0001045032,0.0003570249,0.0003520798,0.0002476847,0.00005284082],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.006321361,0.001980908,0.1445731,0.003270242,0.0004709863,0.000006365843,0.1802307,0.0002434486,0.4075924,0.03902021,0.01975787,0.1965324],"study_design_scores_gemma":[0.01801828,0.02781641,0.6826285,0.0004821736,0.00006566475,0.0004759193,0.1292285,0.00003794623,0.007115878,0.007001753,0.1262917,0.0008372532],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8568545,0.1341902,0.0005609478,0.005864984,0.0008064167,0.001133941,0.00004256448,0.00003275349,0.0005137308],"genre_scores_gemma":[0.9984579,0.0005269746,0.00008776264,0.00009308276,0.00008997261,0.0001410898,0.0001686193,0.00001199245,0.0004226262],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.5380554,"threshold_uncertainty_score":0.4022897,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03062032823657383,"score_gpt":0.2745672877500967,"score_spread":0.2439469595135229,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}