{"id":"W4210547189","doi":"10.1093/emph/eoac003","title":"Immune cell type and DNA methylation vary with reproductive status in women: possible pathways for costs of reproduction","year":2022,"lang":"en","type":"article","venue":"Evolution Medicine and Public Health","topic":"Reproductive System and Pregnancy","field":"Immunology and Microbiology","cited_by":18,"is_retracted":false,"has_abstract":true,"ca_institutions":"BC Children's Hospital; University of British Columbia; Canadian Institute for Advanced Research; University of Manitoba; Children's Hospital Research Institute of Manitoba","funders":"National Heart, Lung, and Blood Institute; Natural Sciences and Engineering Research Council of Canada; Canadian Institute for Advanced Research; National Science Foundation","keywords":"DNA methylation; Reproduction; Immune system; Biology; DNA; Epigenetics; Physiology; Medicine; Immunology; Bioinformatics; Genetics; Gene; Gene expression","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000291081,0.0001069583,0.0002039901,0.0002755882,0.0001349661,0.0002400468,0.0001922057,0.0001764158,0.001803792],"category_scores_gemma":[0.0008158342,0.0001126818,0.0001552393,0.0003742017,0.0001834811,0.0001255368,0.0001607693,0.0001848864,0.0001104122],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001210044,"about_ca_system_score_gemma":0.0001247866,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001309725,"about_ca_topic_score_gemma":0.001577317,"domain_scores_codex":[0.9998401,0.00005754502,0.00000767133,0.00004541761,0.00001712891,0.00003207506],"domain_scores_gemma":[0.99966,0.0001212721,0.0001262822,0.00002862735,0.00002691559,0.00003686764],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0004789463,0.00002178811,0.9681652,0.00004870709,0.0001029869,0.0001277556,0.0002980077,0.00005067515,0.02149848,0.0001633923,0.0001336366,0.008910452],"study_design_scores_gemma":[0.000002303775,0.00005223744,0.9986406,0.000005853052,0.00002094991,0.0001595324,0.0001160104,0.00009377494,0.0005960033,0.000124904,0.0001860457,0.000001781874],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9963118,0.001926417,0.0004281641,0.0001570372,0.000006425127,0.000006726915,0.0004464529,0.000005533035,0.0007114379],"genre_scores_gemma":[0.9992599,0.0002436349,0.0001515403,0.00003068784,0.00000641352,0.000006331623,0.00008746707,0.000001816152,0.0002122882],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001803792,"threshold_uncertainty_score":0.006034255,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03062032823657383,"score_gpt":0.2745672877500967,"score_spread":0.2439469595135229,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}