{"id":"W4210548675","doi":"10.3390/cancers14030765","title":"The Role of Thymine DNA Glycosylase in Transcription, Active DNA Demethylation, and Cancer","year":2022,"lang":"en","type":"review","venue":"Cancers","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":31,"is_retracted":false,"has_abstract":true,"ca_institutions":"Lawson Health Research Institute; Western University","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; Cancer Research Society","keywords":"DNA demethylation; DNA glycosylase; DNA methylation; Biology; Epigenetics; Base excision repair; DNA; DNA repair; Cell biology; Chemistry; Biochemistry; Gene; Gene expression","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002447509,0.0001977001,0.0003894255,0.00006543582,0.0001038032,0.00001194543,0.0001684931,0.0001648719,0.00004271484],"category_scores_gemma":[0.00006405664,0.0001575521,0.0001356712,0.0001979328,0.00009350263,0.00000315183,0.00005134886,0.0001576279,3.036342e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002602635,"about_ca_system_score_gemma":0.0007730705,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002847639,"about_ca_topic_score_gemma":0.0008098794,"domain_scores_codex":[0.9988446,0.0001633141,0.0003661149,0.0003211747,0.0001319231,0.0001729129],"domain_scores_gemma":[0.9993301,0.00006137637,0.0002653572,0.0002478849,0.00004792881,0.00004734152],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00003138139,0.000005445979,0.00003295974,0.0003740453,0.00008708813,3.277578e-7,0.00008465997,0.00007903163,0.004568405,0.00004088454,0.00002763886,0.9946681],"study_design_scores_gemma":[0.0001737082,0.00007663715,0.0000387938,0.0002044939,0.0001214879,6.096204e-7,0.0001039874,0.00001501641,0.01025955,0.0001393354,0.9887022,0.000164217],"study_design_candidate":"design_other","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.006012843,0.9927763,0.00002049899,0.00001343466,0.0001979182,0.0004104813,0.000161585,0.000002771191,0.0004041462],"genre_scores_gemma":[0.004125986,0.9950394,0.00001689569,0.00001105818,0.0001204599,0.000301804,0.000217835,0.00003036837,0.0001361682],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9945039,"threshold_uncertainty_score":0.6424787,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.022155047296653,"score_gpt":0.3045381731463759,"score_spread":0.2823831258497229,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}