{"id":"W4210548675","doi":"10.3390/cancers14030765","title":"The Role of Thymine DNA Glycosylase in Transcription, Active DNA Demethylation, and Cancer","year":2022,"lang":"en","type":"review","venue":"Cancers","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":31,"is_retracted":false,"has_abstract":true,"ca_institutions":"Lawson Health Research Institute; Western University","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; Cancer Research Society","keywords":"DNA demethylation; DNA glycosylase; DNA methylation; Biology; Epigenetics; Base excision repair; DNA; DNA repair; Cell biology; Chemistry; Biochemistry; Gene; Gene expression","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003943669,0.0007361177,0.0009468668,0.00182737,0.0002857333,0.0006444416,0.0007543877,0.0008054167,0.002349508],"category_scores_gemma":[0.0004386316,0.0002214379,0.0003504925,0.002074681,0.0004620379,0.0009300041,0.0006071054,0.001292316,0.00151295],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006496892,"about_ca_system_score_gemma":0.00106065,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001102716,"about_ca_topic_score_gemma":0.001825842,"domain_scores_codex":[0.9998678,0.00002095131,0.00002072537,0.00002361832,0.0000503261,0.00001662607],"domain_scores_gemma":[0.999844,0.00006605621,0.00002263006,0.000005346674,0.00004066858,0.00002130797],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00007470394,0.00005407091,0.0002249758,0.01551614,0.00007378546,0.0003238674,0.00007552227,0.0004133477,0.0033598,0.004052197,0.03058595,0.9452457],"study_design_scores_gemma":[0.00001060422,0.00007292597,0.0008077225,0.001840821,0.00006775398,0.001466763,0.00003857488,0.00006001782,0.0006394854,0.001939014,0.9930408,0.0000154944],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00007603643,0.9989428,0.00007934365,0.0001395738,0.0001760672,0.000001757652,0.0000080543,0.000004836487,0.0005715056],"genre_scores_gemma":[0.0004601562,0.9988669,0.0000781471,0.00007585227,0.000137435,0.000002755927,0.00001734104,7.785044e-7,0.0003606407],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.002349508,"threshold_uncertainty_score":0.007859826,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.022155047296653,"score_gpt":0.3045381731463759,"score_spread":0.2823831258497229,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}