{"id":"W4210555559","doi":"10.3390/jcm11030777","title":"Angiotensin-Converting Enzyme 2 (ACE2), Transmembrane Peptidase Serine 2 (TMPRSS2), and Furin Expression Increases in the Lungs of Patients with Idiopathic Pulmonary Fibrosis (IPF) and Lymphangioleiomyomatosis (LAM): Implications for SARS-CoV-2 (COVID-19) Infections","year":2022,"lang":"en","type":"article","venue":"Journal of Clinical Medicine","topic":"Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis","field":"Medicine","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"St. Paul's Hospital; University of British Columbia","funders":"","keywords":"Furin; Medicine; TMPRSS2; Idiopathic pulmonary fibrosis; Lung; Interstitial lung disease; Angiotensin-converting enzyme 2; Hepatocyte growth factor; ARDS; Gastroenterology; Internal medicine; Pathology; Coronavirus disease 2019 (COVID-19); Biology; Disease; Enzyme; Receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001413305,0.0001774442,0.0002170323,0.0003603924,0.0001195396,0.0002812074,0.00006570699,0.0002245176,0.0008554111],"category_scores_gemma":[0.0002288106,0.0001417666,0.0002024487,0.0001656924,0.0001751243,0.0001643766,0.0001307334,0.0002455586,0.0001077561],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00008871234,"about_ca_system_score_gemma":0.00005746783,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002999462,"about_ca_topic_score_gemma":0.0004585362,"domain_scores_codex":[0.9998928,0.00002069281,0.00001182448,0.00003023738,0.00002151812,0.00002280153],"domain_scores_gemma":[0.9998664,0.00002201195,0.00005747912,0.000006085824,0.00001302794,0.00003501923],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001977062,0.0001615804,0.7274657,0.0001051529,0.0001265733,0.001674566,0.000314898,0.00007779316,0.2587305,0.00005709845,0.0001831606,0.009125846],"study_design_scores_gemma":[0.00001161382,0.0002074404,0.9930705,0.000003830221,0.00003050097,0.00173255,0.0001482186,0.0002110293,0.004387725,0.00002441564,0.0001699398,0.000002218949],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9994928,0.0002683652,0.00007964851,0.00001198126,0.000001805615,0.000001517533,0.00003107228,0.000002373768,0.0001105046],"genre_scores_gemma":[0.9995691,0.0001056553,0.0001091277,0.00001503254,0.00000643849,0.000002893653,0.00005605651,7.426514e-7,0.0001350138],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008554111,"threshold_uncertainty_score":0.002861679,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04216230695847784,"score_gpt":0.3564638620141073,"score_spread":0.3143015550556295,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}