{"id":"W4210561035","doi":"10.1016/j.jaci.2021.12.002","title":"Dupilumab Significantly Reduces Itch and Hives in Patients With Chronic Spontaneous Urticaria: Results From a Phase 3 Trial (LIBERTY-CSU CUPID Study A)","year":2022,"lang":"en","type":"article","venue":"Journal of Allergy and Clinical Immunology","topic":"Urticaria and Related Conditions","field":"Medicine","cited_by":26,"is_retracted":false,"has_abstract":false,"ca_institutions":"Montreal Children's Hospital","funders":"","keywords":"Medicine; Angioedema; Dupilumab; Quality of life (healthcare); Disease; Hereditary angioedema; Chronic urticaria; Dermatology; Atopic dermatitis; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004756711,0.0001594891,0.0007034064,0.0001688543,0.000168346,0.0000172537,0.0001311081,0.0001638905,0.0002215477],"category_scores_gemma":[0.0003907589,0.0001122384,0.0001048349,0.0001517811,0.0002974001,0.0000803684,0.0001091578,0.001355978,0.000001727166],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006252657,"about_ca_system_score_gemma":0.0003340667,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00007103651,"about_ca_topic_score_gemma":0.00009609456,"domain_scores_codex":[0.997328,0.000575604,0.00129581,0.0003103859,0.0002584696,0.0002317759],"domain_scores_gemma":[0.9981569,0.000886102,0.0005006635,0.0002045833,0.0001104716,0.0001412628],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9063311,0.02941197,0.0136221,0.00000231809,0.0237204,0.008072523,0.002726106,0.00003151685,0.0008146522,0.0001370144,0.000341442,0.01478892],"study_design_scores_gemma":[0.4790338,0.09462472,0.4182087,0.00008000074,0.002676455,0.0008260298,0.002884641,0.00007335642,0.00001831691,0.000379081,0.0009670287,0.0002278384],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9960657,0.000953919,0.000003924725,0.001718537,0.0006553979,0.0004563209,0.00003369617,0.000009423752,0.0001030791],"genre_scores_gemma":[0.998614,0.0008486708,0.00005856459,0.00008904196,0.0002049017,0.00001118921,0.00003768528,0.00001497655,0.0001210293],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4272972,"threshold_uncertainty_score":0.5891124,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0177568336888961,"score_gpt":0.3036371032482949,"score_spread":0.2858802695593988,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}