{"id":"W4210565361","doi":"10.3390/biomedicines10020337","title":"Somatostatin-Mediated Regulation of Retinoic Acid-Induced Differentiation of SH-SY5Y Cells: Neurotransmitters Phenotype Characterization","year":2022,"lang":"en","type":"article","venue":"Biomedicines","topic":"Retinal Development and Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":10,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"Science and Engineering Research Board; Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research","keywords":"Synaptophysin; Choline acetyltransferase; Retinoic acid; Neurite; Neurogranin; Glutamate decarboxylase; Cell biology; Biology; SH-SY5Y; Tyrosine hydroxylase; Chemistry; Endocrinology; Dopamine; Biochemistry; Signal transduction; Cholinergic; Neuroblastoma; Cell culture; Enzyme; In vitro","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001120652,0.0002215446,0.0002194084,0.0002001512,0.000122875,0.0001844622,0.0001077675,0.0001434155,0.0007004187],"category_scores_gemma":[0.00007319626,0.00008553944,0.0002311712,0.0001385592,0.0001817791,0.0001773245,0.0001586471,0.0003103574,0.0002237692],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000205064,"about_ca_system_score_gemma":0.0001447574,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009365014,"about_ca_topic_score_gemma":0.002022811,"domain_scores_codex":[0.9999141,0.000008755267,0.00001152167,0.00001874797,0.00002513036,0.00002168688],"domain_scores_gemma":[0.999922,0.00001249326,0.00001977312,0.00001170448,0.00001515156,0.00001887902],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003170921,0.000003180274,0.0001206952,0.00001106153,0.00000143937,0.00003414568,0.00001487241,0.0000102199,0.9994428,0.00002319601,0.000003249048,0.0003035319],"study_design_scores_gemma":[0.000003420479,0.00007918195,0.008293396,0.000002581736,0.00000733083,0.0001374049,0.00003321877,0.0002554404,0.9905273,0.00001624258,0.0006424191,0.000002147208],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9951651,0.001306181,0.001852994,0.00002966001,0.00001721301,0.00001616216,0.0003802154,0.00002420567,0.001208187],"genre_scores_gemma":[0.993947,0.001164754,0.002213706,0.0000247632,0.000006469583,0.00003583437,0.0005319658,0.00001630808,0.002059028],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009365014,"threshold_uncertainty_score":0.002343118,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008008419284424301,"score_gpt":0.2095017967137775,"score_spread":0.2014933774293532,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}