{"id":"W4210565361","doi":"10.3390/biomedicines10020337","title":"Somatostatin-Mediated Regulation of Retinoic Acid-Induced Differentiation of SH-SY5Y Cells: Neurotransmitters Phenotype Characterization","year":2022,"lang":"en","type":"article","venue":"Biomedicines","topic":"Retinal Development and Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":10,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"Science and Engineering Research Board; Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research","keywords":"Synaptophysin; Choline acetyltransferase; Retinoic acid; Neurite; Neurogranin; Glutamate decarboxylase; Cell biology; Biology; SH-SY5Y; Tyrosine hydroxylase; Chemistry; Endocrinology; Dopamine; Biochemistry; Signal transduction; Cholinergic; Neuroblastoma; Cell culture; Enzyme; In vitro","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001070086,0.0001007877,0.0001376399,0.0001168996,0.00005355834,0.000002990255,0.0001029608,0.00004680633,0.00007313294],"category_scores_gemma":[0.00003508389,0.00009595013,0.00004229665,0.0002413496,0.00004770803,0.000004737638,0.00004233812,0.0000365825,0.000001011508],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000007167474,"about_ca_system_score_gemma":0.0000441798,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001101442,"about_ca_topic_score_gemma":0.000001367944,"domain_scores_codex":[0.9991153,0.00007139037,0.0003056432,0.0001786509,0.0002241139,0.0001048967],"domain_scores_gemma":[0.999492,0.00001061528,0.0002516277,0.0001387163,0.00007837768,0.00002859353],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001608974,0.000056245,0.006991916,0.00006792166,0.00002152641,2.631715e-7,0.0002306837,0.000004566125,0.9904721,0.00001078944,0.0001956766,0.001787435],"study_design_scores_gemma":[0.0006377408,0.0003359037,0.1928988,0.00001432685,0.00002087911,9.786709e-7,0.0001450705,0.000211203,0.8042192,0.00001840782,0.001400212,0.00009726868],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9979199,0.00007423185,0.001114072,0.0002555856,0.0003049254,0.0001984667,0.00003385861,0.0000106315,0.00008833357],"genre_scores_gemma":[0.9972779,0.0000597272,0.0001022858,0.0001014935,0.00004611216,0.00001885699,0.002305548,0.00001390161,0.00007413402],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1862529,"threshold_uncertainty_score":0.3912733,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008008419284424301,"score_gpt":0.2095017967137775,"score_spread":0.2014933774293532,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}