{"id":"W4210565794","doi":"10.21203/rs.3.rs-25157/v5","title":"Depressive Effectiveness of Vigabatrin (y-Vinyl-GABA), an Antiepileptic Drug, in Intermediate-conductance Calcium-Activated Potassium Channels in Human Glioma Cells","year":2021,"lang":"en","type":"preprint","venue":"Research Square","topic":"Neuroscience and Neuropharmacology Research","field":"Neuroscience","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University","funders":"National Cheng Kung University Hospital; National Cheng Kung University; Ministry of Science and Technology, Taiwan","keywords":"Vigabatrin; Glioma; Conductance; Potassium; Drug; Antiepileptic drug; Calcium; Pharmacology; Chemistry; Neuroscience; Epilepsy; Medicine; Psychology; Anticonvulsant; Cancer research; Physics; Organic chemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009881444,0.0001316495,0.0002276366,0.0001136632,0.0001199493,0.0002978588,0.0002130189,0.0002145141,0.001070474],"category_scores_gemma":[0.0001825865,0.00007558183,0.0002147139,0.0001608564,0.000174038,0.0002066957,0.0001218013,0.0003594603,0.0001995258],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003233273,"about_ca_system_score_gemma":0.0002318424,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.004432259,"about_ca_topic_score_gemma":0.002971689,"domain_scores_codex":[0.9998859,0.0000239944,0.00001165615,0.00001685725,0.00001671581,0.00004481704],"domain_scores_gemma":[0.9999436,0.00002135377,0.000005856683,0.000007910645,0.000005480641,0.00001574082],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001652756,0.000131209,0.0005840563,0.00005693529,0.00002077612,0.0001290807,0.00009796202,0.0001932879,0.9945463,0.0004247877,0.0002016617,0.001961291],"study_design_scores_gemma":[0.0003486239,0.003083601,0.03294971,0.00001501658,0.00009845272,0.0004384526,0.0003368737,0.003746246,0.9564753,0.0002377108,0.002252392,0.00001757956],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9984435,0.0003509366,0.000106815,0.00003748046,0.00001947047,0.00000424972,0.0002155217,0.000009144898,0.0008128372],"genre_scores_gemma":[0.9988266,0.0002484959,0.00007226298,0.00001657936,0.000003421889,0.000005303419,0.0001580236,0.000002352453,0.0006669469],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004432259,"threshold_uncertainty_score":0.008812904,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0979261988271786,"score_gpt":0.4315609640915465,"score_spread":0.3336347652643679,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}