{"id":"W4210582840","doi":"10.1038/s41586-022-04447-0","title":"Human genetic and immunological determinants of critical COVID-19 pneumonia","year":2022,"lang":"en","type":"review","venue":"Nature","topic":"Respiratory viral infections research","field":"Medicine","cited_by":391,"is_retracted":false,"has_abstract":false,"ca_institutions":"BC Children's Hospital; McGill University Health Centre; Hospital for Sick Children; St. Paul's Hospital; University of British Columbia","funders":"National Center for Advancing Translational Sciences; National Institute of Allergy and Infectious Diseases; National Institutes of Health; Howard Hughes Medical Institute; Agence Nationale de la Recherche; National Human Genome Research Institute","keywords":"Pneumonia; Immunology; TLR7; Disease; Immunity; Medicine; Viral pneumonia; Atypical pneumonia; Immune system; Antibody; Biology; Coronavirus disease 2019 (COVID-19); Innate immune system; Internal medicine; Infectious disease (medical specialty); Toll-like receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["research_integrity","insufficient_payload"],"consensus_categories":["research_integrity"],"category_scores_codex":[0.0003483944,0.0002617026,0.00134946,0.0003648041,0.0002054969,0.00001974679,0.0002300006,0.002131117,0.001412796],"category_scores_gemma":[0.002918093,0.0001906028,0.0002739578,0.0004202787,0.0004446252,0.00002537403,0.00032365,0.006098331,0.0000156371],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002564287,"about_ca_system_score_gemma":0.0006015875,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001362515,"about_ca_topic_score_gemma":0.000003931621,"domain_scores_codex":[0.9979012,0.0004208615,0.0004969165,0.0004438254,0.0004567897,0.0002804324],"domain_scores_gemma":[0.9986457,0.000426038,0.0001128106,0.0005036723,0.00006530289,0.0002465324],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00001897648,0.0002705824,0.0006031779,0.04341207,0.0001023032,0.001192651,0.00001797447,6.196908e-8,0.00008219237,0.0002764522,0.000783552,0.95324],"study_design_scores_gemma":[0.0002250391,0.0007230688,0.00110365,0.0008999582,0.0003654987,0.001178333,0.000007990507,9.965947e-7,0.000003632755,0.00006081598,0.9952779,0.0001531266],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.001752499,0.9968009,8.470922e-7,0.00007775522,0.0001255701,0.0007006786,0.00005413772,0.00003798992,0.0004496134],"genre_scores_gemma":[0.001580905,0.9973071,0.00007130319,0.0003624079,0.0001096672,0.0001402677,0.0000235359,0.00003969951,0.0003650867],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9944943,"threshold_uncertainty_score":0.9995,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.150336585385673,"score_gpt":0.5185498893204863,"score_spread":0.3682133039348133,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}