{"id":"W4210585739","doi":"10.21203/rs.3.rs-28977/v1","title":"S. Aureus Lipoteichoic Acid Failed to Activate NLRP3, but Downregulated the Transduction of NLRP3/MAPK and NF-κB Signaling Pathway in Mouse Mastitis Induced by S. Aureus","year":2020,"lang":"en","type":"preprint","venue":"Research Square (Research Square)","topic":"Immune Response and Inflammation","field":"Immunology and Microbiology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"National Natural Science Foundation of China","keywords":"Lipoteichoic acid; MAPK/ERK pathway; Inflammation; Signal transduction; Staphylococcus aureus; Innate immune system; Immune system; NF-κB; Mastitis; Mammary gland; Immunology; Cell biology; Chemistry; Biology; Medicine; Microbiology; Internal medicine; Bacteria","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","research_integrity"],"consensus_categories":["research_integrity"],"category_scores_codex":[0.01109946,0.000852003,0.0013941,0.002611868,0.001123773,0.0003711989,0.002028987,0.002024058,0.0008133868],"category_scores_gemma":[0.004347762,0.0007175655,0.0003580384,0.002623562,0.001230646,0.0004538809,0.002230615,0.009018325,0.0004161742],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008491023,"about_ca_system_score_gemma":0.001731629,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.005419602,"about_ca_topic_score_gemma":0.0003714012,"domain_scores_codex":[0.9815813,0.01088314,0.001622134,0.001898169,0.001488946,0.00252634],"domain_scores_gemma":[0.9929683,0.002531626,0.0003541865,0.001786034,0.002033635,0.0003261772],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.003951623,0.0003464591,0.0001338478,0.001016068,0.0004224819,0.00005199037,0.00709532,0.0002325532,0.9674048,0.0002256477,0.002771481,0.01634768],"study_design_scores_gemma":[0.002254785,0.001733752,0.002385136,0.001181875,0.00002494424,0.0000128473,0.003721884,0.0001339667,0.9791822,0.0008118564,0.007895756,0.0006609903],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9797647,0.005570652,0.0003588172,0.007578806,0.0003984117,0.005398386,0.0005456274,0.0001758369,0.0002087755],"genre_scores_gemma":[0.9945458,0.001279307,0.0000683569,0.00004367871,0.0002000181,0.001064205,0.001124247,0.00015558,0.001518764],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01568669,"threshold_uncertainty_score":0.9995276,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06178101398819199,"score_gpt":0.3423510422098112,"score_spread":0.2805700282216192,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}