{"id":"W4210585739","doi":"10.21203/rs.3.rs-28977/v1","title":"S. Aureus Lipoteichoic Acid Failed to Activate NLRP3, but Downregulated the Transduction of NLRP3/MAPK and NF-κB Signaling Pathway in Mouse Mastitis Induced by S. Aureus","year":2020,"lang":"en","type":"preprint","venue":"Research Square (Research Square)","topic":"Immune Response and Inflammation","field":"Immunology and Microbiology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"National Natural Science Foundation of China","keywords":"Lipoteichoic acid; MAPK/ERK pathway; Inflammation; Signal transduction; Staphylococcus aureus; Innate immune system; Immune system; NF-κB; Mastitis; Mammary gland; Immunology; Cell biology; Chemistry; Biology; Medicine; Microbiology; Internal medicine; Bacteria","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002010438,0.0005601053,0.0003679631,0.000304548,0.0001544566,0.0002836794,0.0001446653,0.0004023814,0.001595059],"category_scores_gemma":[0.0001067218,0.0001581529,0.0004956399,0.0001307486,0.0003283062,0.0002889897,0.0001928783,0.00104875,0.00034105],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002378672,"about_ca_system_score_gemma":0.0002684836,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004147929,"about_ca_topic_score_gemma":0.0006194406,"domain_scores_codex":[0.9997439,0.00003847583,0.00003417568,0.00005014683,0.0000722,0.00006108234],"domain_scores_gemma":[0.9998511,0.00001241982,0.00005034907,0.00001604837,0.00002172897,0.00004835591],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001595991,0.00003397439,0.00006888248,0.00004671604,0.000002821971,0.00002713447,0.000008371181,0.00001059902,0.9992872,0.00002062798,0.00001152404,0.0003225747],"study_design_scores_gemma":[0.00002453585,0.001075217,0.003482592,0.00001806843,0.00002682777,0.0001700399,0.00005905885,0.0004623723,0.9933015,0.00006090098,0.001313852,0.000004958631],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9894676,0.004277941,0.00415847,0.0002595627,0.0001110125,0.0000626294,0.0005244729,0.0001022941,0.001036008],"genre_scores_gemma":[0.9901097,0.001879497,0.00316947,0.0001532357,0.00003088576,0.0001298558,0.0005678578,0.00002307427,0.003936439],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001595059,"threshold_uncertainty_score":0.005335987,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06178101398819199,"score_gpt":0.3423510422098112,"score_spread":0.2805700282216192,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}