{"id":"W4210592713","doi":"10.1021/acsptsci.1c00192","title":"Labeling Cell Surface Receptors with Ligand.BirA* Bispecifics","year":2022,"lang":"en","type":"article","venue":"ACS Pharmacology & Translational Science","topic":"Biotin and Related Studies","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Sunnybrook Health Science Centre","funders":"Canadian Institutes of Health Research","keywords":"Biotinylation; Receptor; Ligand (biochemistry); Chemistry; Cell biology; Biochemistry; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000412393,0.0001201334,0.000091061,0.000047018,0.0009618387,0.00001431822,0.000337493,0.00005627915,0.0001358683],"category_scores_gemma":[0.000003729763,0.0001036502,0.00003336401,0.0004886583,0.0005475491,0.000008619586,0.0001089805,0.0002400143,0.000008602641],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002177346,"about_ca_system_score_gemma":0.0002638914,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000005412624,"about_ca_topic_score_gemma":0.000004652784,"domain_scores_codex":[0.9987604,0.00005496642,0.0001414998,0.000410678,0.0003275887,0.0003048933],"domain_scores_gemma":[0.9996458,0.00002418305,0.00005881654,0.00009695138,0.00009988034,0.00007439576],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009371682,0.00008224387,0.002806619,0.000003396701,0.00003143304,0.000003562318,0.0001972409,0.0120346,0.9817661,0.00009085506,0.002664375,0.0002258863],"study_design_scores_gemma":[0.001047603,0.0003412878,0.0009125718,0.000002081798,0.00004379764,0.00002629172,0.0002158104,0.000268332,0.8970916,0.00004658886,0.09975702,0.0002470458],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9918947,0.002062021,0.0003479597,0.001752159,0.0007669248,0.0001731905,0.00002386049,0.00002148868,0.00295767],"genre_scores_gemma":[0.9963624,0.0003625105,0.001719509,0.0006705815,0.00009687125,0.00001234504,0.0000308099,0.00001119158,0.0007337579],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.09709264,"threshold_uncertainty_score":0.7397783,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009949949622523178,"score_gpt":0.2591795096771473,"score_spread":0.2492295600546241,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}