{"id":"W4210593866","doi":"10.1016/j.tcm.2022.01.009","title":"Editorial commentary: Mef2 regulated cardiac hypertrophy and heart failure in hypertension","year":2022,"lang":"en","type":"review","venue":"Trends in Cardiovascular Medicine","topic":"Cardiovascular Function and Risk Factors","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Manitoba; St. Boniface Hospital","funders":"","keywords":"Histone; GLUT4; Chromatin immunoprecipitation; Acetylation; Mef2; Gene; Biology; Chromatin; Regulation of gene expression; Phosphorylation; Downregulation and upregulation; Transcriptional regulation; Gene expression; Epigenetics; Cell biology; Molecular biology; Genetics; Promoter; Enhancer; Chromosomal translocation","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.005184878,0.001950779,0.003841199,0.001973307,0.00102439,0.003661297,0.002638811,0.0114252,0.01377961],"category_scores_gemma":[0.01372,0.0006816205,0.001992157,0.001247571,0.001414316,0.002698479,0.00200351,0.01182791,0.00758039],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001347257,"about_ca_system_score_gemma":0.003576363,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001393808,"about_ca_topic_score_gemma":0.003157874,"domain_scores_codex":[0.9974939,0.000704534,0.0004293345,0.0003170827,0.0008593723,0.0001958126],"domain_scores_gemma":[0.9932287,0.002800257,0.0007976908,0.0001464212,0.002370423,0.0006565466],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001029862,0.00001193224,0.00003038228,0.001859282,0.00007277598,0.00008294064,0.00002603362,0.00001700693,0.00009109195,0.0002343055,0.9841372,0.01333409],"study_design_scores_gemma":[0.0004186291,0.00009451098,0.0005266756,0.004276729,0.0004516652,0.0004049983,0.00007825527,0.000103268,0.0001532418,0.001492583,0.9919623,0.00003712454],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"editorial","genre_gemma":"editorial","genre_scores_codex":[0.0001125787,0.1071944,0.0001838541,0.1123986,0.7783937,0.00003838371,0.0003237775,0.00006710851,0.00128755],"genre_scores_gemma":[0.0012963,0.09425888,0.0002280083,0.1852928,0.7104493,0.00008618517,0.0002176877,0.00004965025,0.008121132],"genre_candidate":"editorial","genre_consensus":"editorial","teacher_disagreement_score":0.01377961,"threshold_uncertainty_score":0.0460974,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03330564413939171,"score_gpt":0.288041677685287,"score_spread":0.2547360335458953,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}