{"id":"W4210601252","doi":"10.1002/ange.202110819","title":"High‐Affinity Dimeric Aptamers Enable the Rapid Electrochemical Detection of Wild‐Type and B.1.1.7 SARS‐CoV‐2 in Unprocessed Saliva","year":2021,"lang":"en","type":"article","venue":"Angewandte Chemie","topic":"SARS-CoV-2 detection and testing","field":"Medicine","cited_by":30,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University Medical Centre; McMaster University","funders":"Institute of Infection and Immunity; Canadian Institutes of Health Research; McMaster University","keywords":"Saliva; Aptamer; Wild type; Dissociation constant; Chemistry; Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2); Coronavirus disease 2019 (COVID-19); Electrochemistry; Molecular biology; Chromatography; Virology; Electrode; Biology; Receptor; Biochemistry; Medicine; Mutant; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001942842,0.0001576937,0.000309889,0.00007322554,0.00006729936,0.00001639511,0.00006281073,0.0001071329,0.00002580584],"category_scores_gemma":[0.0009168212,0.0001283587,0.00005515897,0.001062789,0.0001123446,0.00006738405,0.00003461402,0.0003437513,0.000004299501],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000667899,"about_ca_system_score_gemma":0.0001370651,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002130705,"about_ca_topic_score_gemma":0.00008065597,"domain_scores_codex":[0.9989579,0.00003552416,0.0002670512,0.0002938075,0.0001886608,0.0002570945],"domain_scores_gemma":[0.999223,0.0001877082,0.0001088354,0.0002356056,0.000205651,0.00003922687],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001294196,0.00007933038,0.001198171,0.0001076116,0.00004285676,0.00001663649,0.0001763852,1.804617e-7,0.99631,0.00000407235,0.0001057433,0.001829602],"study_design_scores_gemma":[0.001132138,0.0001168841,0.001113851,0.00007686469,0.00007685141,0.0001164957,0.0002365954,0.00002902309,0.9950972,0.0001031807,0.001775708,0.0001252368],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9963697,0.001474671,0.00004409349,0.0002980089,0.0001180264,0.0001354889,9.867655e-7,0.00006449683,0.001494577],"genre_scores_gemma":[0.9982882,0.000150629,0.000281992,0.001076731,0.00009892602,0.00001291562,0.00001122646,0.00002267909,0.0000567213],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001918529,"threshold_uncertainty_score":0.5234314,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02628962778560489,"score_gpt":0.2660237275038137,"score_spread":0.2397340997182088,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}