{"id":"W4210601252","doi":"10.1002/ange.202110819","title":"High‐Affinity Dimeric Aptamers Enable the Rapid Electrochemical Detection of Wild‐Type and B.1.1.7 SARS‐CoV‐2 in Unprocessed Saliva","year":2021,"lang":"en","type":"article","venue":"Angewandte Chemie","topic":"SARS-CoV-2 detection and testing","field":"Medicine","cited_by":30,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University Medical Centre; McMaster University","funders":"Institute of Infection and Immunity; Canadian Institutes of Health Research; McMaster University","keywords":"Saliva; Aptamer; Wild type; Dissociation constant; Chemistry; Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2); Coronavirus disease 2019 (COVID-19); Electrochemistry; Molecular biology; Chromatography; Virology; Electrode; Biology; Receptor; Biochemistry; Medicine; Mutant; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003615885,0.0004502252,0.0002011244,0.000248826,0.00009221856,0.000281284,0.0002665439,0.0006239337,0.0008791944],"category_scores_gemma":[0.0003244263,0.0002497968,0.0001714683,0.0001127979,0.0001782171,0.0001922774,0.0002085686,0.0003408296,0.0004152885],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001919989,"about_ca_system_score_gemma":0.0001172297,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002634796,"about_ca_topic_score_gemma":0.000459323,"domain_scores_codex":[0.999655,0.00007860716,0.00002020902,0.00007549403,0.000135069,0.00003563774],"domain_scores_gemma":[0.9999001,0.00002764544,0.00002085597,0.000007637283,0.00002590086,0.00001792898],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002915517,0.00001367466,0.0003158771,0.00002111449,0.000003448447,0.00001574702,0.00001399227,0.00004557721,0.9966511,0.00003603728,0.00004725523,0.00280709],"study_design_scores_gemma":[0.000009481644,0.0002539522,0.002058144,0.000003862892,0.000009981411,0.0003290629,0.0000210656,0.002550032,0.9936382,0.00003850429,0.001080307,0.000007315927],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9545429,0.003114969,0.03919854,0.0002507031,0.00010534,0.000106638,0.0002289525,0.0002830516,0.002169002],"genre_scores_gemma":[0.9658352,0.0004582801,0.03151502,0.0001372672,0.00001631436,0.00004224582,0.0001318914,0.000007879447,0.001855907],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008791944,"threshold_uncertainty_score":0.002941191,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02628962778560489,"score_gpt":0.2660237275038137,"score_spread":0.2397340997182088,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}