{"id":"W4210602489","doi":"10.1212/wnl.0000000000200035","title":"Association of CSF, Plasma, and Imaging Markers of Neurodegeneration With Clinical Progression in People With Subjective Cognitive Decline","year":2022,"lang":"en","type":"article","venue":"Neurology","topic":"Amyotrophic Lateral Sclerosis Research","field":"Medicine","cited_by":76,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Avid Radiopharmaceuticals; IXICO; GIESKES-STRIJBIS FONDS; Amsterdam Neuroscience; Stichting Dioraphte; University College London Hospitals NHS Foundation Trust; Sanofi; European Commission; University College London; ZonMw; Kyowa Kirin Pharmaceutical Development; Nederlandse Organisatie voor Wetenschappelijk Onderzoek; Weston Brain Institute; National Institute for Health and Care Research; Teva Pharmaceutical Industries; Alzheimer Nederland; EU Joint Programme – Neurodegenerative Disease Research; Biogen","keywords":"Cognitive decline; Association (psychology); Neurodegeneration; Cognition; Neuroimaging; Disease","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001250295,0.0004886038,0.00043144,0.001250805,0.0004182046,0.0006742695,0.0003486661,0.0006324123,0.001075938],"category_scores_gemma":[0.003559311,0.0002656991,0.0004630844,0.0008234505,0.0003001722,0.0004522393,0.0005082582,0.0004171392,0.000153732],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002505914,"about_ca_system_score_gemma":0.0003078857,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.005918384,"about_ca_topic_score_gemma":0.006110869,"domain_scores_codex":[0.9995824,0.00013168,0.00005869984,0.0001026624,0.00007060842,0.00005386697],"domain_scores_gemma":[0.9979547,0.0004281666,0.0009553672,0.0001474541,0.0002978421,0.0002162855],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0003508267,0.00003362726,0.9981986,0.00001224608,0.00006840715,0.0000352495,0.00003194903,0.00003686493,0.0001267096,0.000004527608,0.0000341238,0.001067009],"study_design_scores_gemma":[0.00001642263,0.0001923728,0.9991154,0.000008204718,0.00004568327,0.0001535369,0.00006824449,0.0002093348,0.00008009464,0.00004003069,0.00006639465,0.000004253812],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9989321,0.0004745284,0.00009929027,0.00002376244,0.00000499594,0.00001024252,0.0002571719,0.000003703876,0.0001942764],"genre_scores_gemma":[0.9992689,0.00009871325,0.0001622923,0.00002556188,0.00001491404,0.00001434463,0.0002838124,0.000001098548,0.0001303764],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005918384,"threshold_uncertainty_score":0.01176786,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01467423437096305,"score_gpt":0.3159409967232243,"score_spread":0.3012667623522613,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}