{"id":"W4210602489","doi":"10.1212/wnl.0000000000200035","title":"Association of CSF, Plasma, and Imaging Markers of Neurodegeneration With Clinical Progression in People With Subjective Cognitive Decline","year":2022,"lang":"en","type":"article","venue":"Neurology","topic":"Amyotrophic Lateral Sclerosis Research","field":"Medicine","cited_by":76,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Avid Radiopharmaceuticals; IXICO; GIESKES-STRIJBIS FONDS; Amsterdam Neuroscience; Stichting Dioraphte; University College London Hospitals NHS Foundation Trust; Sanofi; European Commission; University College London; ZonMw; Kyowa Kirin Pharmaceutical Development; Nederlandse Organisatie voor Wetenschappelijk Onderzoek; Weston Brain Institute; National Institute for Health and Care Research; Teva Pharmaceutical Industries; Alzheimer Nederland; EU Joint Programme – Neurodegenerative Disease Research; Biogen","keywords":"Cognitive decline; Association (psychology); Neurodegeneration; Cognition; Neuroimaging; Disease","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005641123,0.00007439202,0.0002826304,0.0001178966,0.00004125874,0.000002986433,0.00003934693,0.00004427426,0.0000388536],"category_scores_gemma":[0.0002698191,0.0000560951,0.00001976066,0.0002662885,0.0001121459,0.00005054967,0.0001079295,0.0004291556,2.771926e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003393822,"about_ca_system_score_gemma":0.000114694,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001640714,"about_ca_topic_score_gemma":0.0004859332,"domain_scores_codex":[0.9983833,0.0005655357,0.0002732993,0.0002555369,0.0003598633,0.000162458],"domain_scores_gemma":[0.9990141,0.0004558715,0.0002279544,0.00008069783,0.0001771208,0.00004425494],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.01781828,0.0002171129,0.9756103,0.00001981958,0.0000312173,0.00004157646,0.0001710134,0.00007365885,0.003181759,0.00000547628,0.00001534912,0.0028144],"study_design_scores_gemma":[0.004129795,0.008169096,0.981746,0.00001976808,0.00004424383,0.00005540005,0.00003975009,0.005306461,0.0004214893,0.000008853261,0.00001696842,0.00004217734],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9960491,0.00001946759,0.00002808708,0.003243428,0.00003367246,0.0004848462,0.000008886927,0.00000838915,0.0001241397],"genre_scores_gemma":[0.9993395,0.00003263652,0.0001195919,0.0003786264,0.00002157413,0.00005047621,0.00002042942,0.00001402768,0.00002314375],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01368849,"threshold_uncertainty_score":0.2287492,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01467423437096305,"score_gpt":0.3159409967232243,"score_spread":0.3012667623522613,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}