{"id":"W4210604230","doi":"10.3390/biomedicines10020319","title":"Metformin Inhibits ROS Production by Human M2 Macrophages via the Activation of AMPK","year":2022,"lang":"en","type":"article","venue":"Biomedicines","topic":"Metabolism, Diabetes, and Cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":59,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Centre National de la Recherche Scientifique; Agence Universitaire de la Francophonie; Institut National de la Santé et de la Recherche Médicale; Agence Nationale de la Recherche","keywords":"Metformin; AMPK; Proinflammatory cytokine; Chemistry; Macrophage; Reactive oxygen species; Inflammation; Mitochondrial ROS; Monocyte; Cell biology; Adipose tissue macrophages; Activator (genetics); In vitro; Pharmacology; Protein kinase A; Endocrinology; Kinase; Biology; Immunology; Adipose tissue; Biochemistry; Diabetes mellitus; Receptor; White adipose tissue","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002227033,0.0004307104,0.0002783299,0.0002402254,0.000174071,0.0001896447,0.0001464074,0.0002273182,0.001289252],"category_scores_gemma":[0.00006996211,0.0001179457,0.0002255619,0.0001556721,0.0001214456,0.0001149038,0.0001682355,0.0004198696,0.000321412],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001407534,"about_ca_system_score_gemma":0.0002355143,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00030626,"about_ca_topic_score_gemma":0.0006124927,"domain_scores_codex":[0.9998878,0.00002987965,0.00001441367,0.00001594691,0.00002272296,0.00002914627],"domain_scores_gemma":[0.9999667,0.000004587189,0.00001100943,0.000003985229,0.000006115398,0.000007616458],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001215407,0.0002426871,0.0003061431,0.0001587103,0.00001373151,0.00007669783,0.00001840916,0.00007181304,0.9930021,0.0002049571,0.0002439562,0.004445353],"study_design_scores_gemma":[0.0002692226,0.001378713,0.004000985,0.0000160303,0.0000289594,0.0002158966,0.00002679165,0.0005781437,0.982761,0.00007304609,0.01064472,0.000006493729],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9779098,0.01175605,0.004504341,0.0005193171,0.0002836752,0.0001897623,0.0006540724,0.00009765489,0.004085398],"genre_scores_gemma":[0.9795324,0.007550555,0.004986226,0.0002812187,0.0001050883,0.0003307147,0.0009663036,0.00002251304,0.006225018],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001289252,"threshold_uncertainty_score":0.004312992,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008118780406730738,"score_gpt":0.2488481556849681,"score_spread":0.2407293752782374,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}