{"id":"W4210604509","doi":"10.2967/jnumed.121.263254","title":"First-in-Humans Evaluation of <sup>18</sup>F-SMBT-1, a Novel <sup>18</sup>F-Labeled Monoamine Oxidase-B PET Tracer for Imaging Reactive Astrogliosis","year":2022,"lang":"en","type":"article","venue":"Journal of Nuclear Medicine","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":68,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Aging","funders":"National Health and Medical Research Council; Medical Research Council; University of Pittsburgh","keywords":"Astrogliosis; Selegiline; Monoamine oxidase B; Neurodegeneration; Chemistry; Gliosis; Monoamine oxidase; White matter; Pittsburgh compound B; Magnetic resonance imaging; Nuclear medicine; Internal medicine; Neuroscience; Alzheimer's disease; Medicine; Pathology; Psychology; Biochemistry; Parkinson's disease; Central nervous system; Disease; Enzyme","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.003037205,0.000385718,0.001143129,0.001040664,0.0002841512,0.00001909477,0.0003129942,0.00006385682,0.004161207],"category_scores_gemma":[0.00128013,0.0003109324,0.0004018795,0.0006546701,0.0002341626,0.0003659265,0.0001129883,0.0008097612,0.00001031336],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001027446,"about_ca_system_score_gemma":0.0005580788,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001362062,"about_ca_topic_score_gemma":0.000007891717,"domain_scores_codex":[0.9945629,0.0002965918,0.001275569,0.0004380795,0.002776615,0.0006502839],"domain_scores_gemma":[0.9963578,0.0004814643,0.0008253579,0.0004558439,0.001298315,0.0005812035],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"simulation_or_modeling","study_design_scores_codex":[0.1165022,0.06614465,0.1622235,0.00393571,0.07864655,0.01086922,0.05862243,0.05694872,0.09200889,0.0007531141,0.2851348,0.06821021],"study_design_scores_gemma":[0.1798707,0.0241067,0.1177686,0.004277967,0.01990303,0.003575063,0.0485534,0.5747039,0.000799871,0.0009034895,0.02438823,0.001149021],"study_design_candidate":"simulation_or_modeling","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9812874,0.004528941,0.00008732934,0.01092039,0.0001102875,0.001891013,0.0001562991,0.00002861249,0.0009896925],"genre_scores_gemma":[0.9971198,0.0001834557,0.001350653,0.0004430902,0.0005442098,0.0001106977,0.0000770795,0.0001098004,0.0000611916],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.5177552,"threshold_uncertainty_score":0.9999343,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0631678560740018,"score_gpt":0.3546692850561562,"score_spread":0.2915014289821545,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}