{"id":"W4210604509","doi":"10.2967/jnumed.121.263254","title":"First-in-Humans Evaluation of <sup>18</sup>F-SMBT-1, a Novel <sup>18</sup>F-Labeled Monoamine Oxidase-B PET Tracer for Imaging Reactive Astrogliosis","year":2022,"lang":"en","type":"article","venue":"Journal of Nuclear Medicine","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":68,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Aging","funders":"National Health and Medical Research Council; Medical Research Council; University of Pittsburgh","keywords":"Astrogliosis; Selegiline; Monoamine oxidase B; Neurodegeneration; Chemistry; Gliosis; Monoamine oxidase; White matter; Pittsburgh compound B; Magnetic resonance imaging; Nuclear medicine; Internal medicine; Neuroscience; Alzheimer's disease; Medicine; Pathology; Psychology; Biochemistry; Parkinson's disease; Central nervous system; Disease; Enzyme","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001705546,0.001367904,0.0008749465,0.0002016147,0.0007128522,0.0009090928,0.0005931135,0.001820777,0.003114005],"category_scores_gemma":[0.0007862828,0.0007291756,0.0006061912,0.0001442175,0.001108496,0.0008052322,0.000348035,0.001214454,0.001457932],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00075494,"about_ca_system_score_gemma":0.000649221,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00181602,"about_ca_topic_score_gemma":0.00238215,"domain_scores_codex":[0.9996744,0.0001296325,0.00001360393,0.00008477234,0.00003544482,0.00006223247],"domain_scores_gemma":[0.999598,0.00005328768,0.00006189089,0.00009214778,0.00007826256,0.0001164614],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.08510853,0.01907035,0.02764259,0.001945661,0.001484189,0.002451326,0.00103293,0.001180205,0.7328832,0.001030414,0.01494023,0.1112305],"study_design_scores_gemma":[0.0108244,0.3943725,0.06420274,0.0002228368,0.003648495,0.01889155,0.0009706944,0.006440612,0.4063152,0.0015554,0.09225345,0.0003021568],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9760854,0.007370482,0.009151999,0.0006267616,0.000206119,0.00131844,0.00126661,0.0002866533,0.003687549],"genre_scores_gemma":[0.9793632,0.003834149,0.007782842,0.001176436,0.0001260264,0.00101802,0.002091179,0.000131031,0.00447714],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003114005,"threshold_uncertainty_score":0.0104174,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0631678560740018,"score_gpt":0.3546692850561562,"score_spread":0.2915014289821545,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}