{"id":"W4210607306","doi":"10.1093/nar/gkac097","title":"DNA methylation cues in nucleosome geometry, stability and unwrapping","year":2022,"lang":"en","type":"article","venue":"Nucleic Acids Research","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":52,"is_retracted":false,"has_abstract":true,"ca_institutions":"Queen's University","funders":"National Institutes of Health; Natural Sciences and Engineering Research Council of Canada; Canada Research Chairs; Ontario Institute for Cancer Research","keywords":"Nucleosome; Linker DNA; Biology; Histone octamer; Chromatosome; DNA methylation; DNA; Histone; Histone methylation; Biophysics; Cytosine; Epigenetics; 5-Methylcytosine; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000111499,0.0001600384,0.0001539194,0.0001056947,0.0002346984,0.0002413651,0.0002646357,0.0002396515,0.0007253599],"category_scores_gemma":[0.0004997353,0.0002056645,0.0001925478,0.0001057294,0.0002947227,0.0002990687,0.0002555253,0.0002796862,0.00007405096],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003592909,"about_ca_system_score_gemma":0.0003179768,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00266916,"about_ca_topic_score_gemma":0.003267855,"domain_scores_codex":[0.9999503,0.00001016623,0.000002095285,0.00001129341,0.00001344917,0.00001261773],"domain_scores_gemma":[0.9999195,0.00003164109,0.00001294459,0.000008833228,0.0000112768,0.0000157282],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"simulation_or_modeling","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003509514,0.0001300002,0.008705764,0.00009801955,0.00008429732,0.0002443154,0.0001943695,0.5039628,0.472605,0.005485191,0.0002012554,0.007938047],"study_design_scores_gemma":[0.00006260635,0.0002571606,0.01237323,0.00001129333,0.00004422991,0.0000736729,0.0001113769,0.9234585,0.06011693,0.002536444,0.0009184122,0.0000361657],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9960837,0.00008298369,0.003128794,0.00003527843,0.000007012758,0.000004843654,0.0000456647,0.00002625436,0.0005854476],"genre_scores_gemma":[0.9984914,0.00008474763,0.001262144,0.000008259397,0.000001509671,0.000006257853,0.00003802625,0.00001232692,0.00009526998],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00266916,"threshold_uncertainty_score":0.005307257,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05592352791928044,"score_gpt":0.3465435547248631,"score_spread":0.2906200268055826,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}