{"id":"W4210617201","doi":"10.1093/jcag/gwac001","title":"Cost-Effectiveness of Tight Control for Crohn’s Disease With Adalimumab-Based Treatment: Economic Evaluation of the CALM Trial From a Canadian Perspective","year":2022,"lang":"en","type":"article","venue":"Journal of the Canadian Association of Gastroenterology","topic":"Inflammatory Bowel Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"ABB (Canada); Queen Elizabeth II Health Sciences Centre; Mount Sinai Hospital; London Health Sciences Centre; McGill University; University of Calgary; University of British Columbia","funders":"Relypsa; Takeda Canada; Allergan; Genentech; Atlantic Healthcare; Novo Nordisk; Eisai; AbbVie; Celgene; Biogen; Gilead Sciences; Amgen; Pfizer; AstraZeneca; Eli Lilly and Company; Bristol-Myers Squibb","keywords":"Adalimumab; Medicine; Absenteeism; Indirect costs; Internal medicine; Inflammatory bowel disease; Quality of life (healthcare); Randomized controlled trial; Crohn's disease; Physical therapy; Disease; Psychology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.009154069,0.001957003,0.00246449,0.001553147,0.001047595,0.002673363,0.00217908,0.001688468,0.003755192],"category_scores_gemma":[0.02648845,0.0005970138,0.005251299,0.002772385,0.001265987,0.0008076013,0.001459407,0.002466376,0.0001371773],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.06272017,"about_ca_system_score_gemma":0.04268118,"about_ca_topic_candidate":true,"about_ca_topic_consensus":true,"about_ca_topic_score_codex":0.848983,"about_ca_topic_score_gemma":0.8206698,"domain_scores_codex":[0.9921882,0.004807543,0.0003574864,0.000399941,0.001442871,0.0008039563],"domain_scores_gemma":[0.9923269,0.003927767,0.001059214,0.0003024125,0.001363904,0.001019741],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"observational","study_design_scores_codex":[0.3563804,0.004427517,0.05184874,0.02010176,0.04185519,0.0006857848,0.0006625119,0.2755216,0.001515586,0.02454648,0.0292251,0.1932293],"study_design_scores_gemma":[0.2029166,0.03129548,0.1640143,0.009404129,0.07267416,0.0007826599,0.001369074,0.4640359,0.001891519,0.01365757,0.03680881,0.001149815],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8299211,0.09566529,0.003512545,0.00967317,0.0005834542,0.004565612,0.02943348,0.0001651342,0.02648024],"genre_scores_gemma":[0.9827696,0.007613863,0.002795905,0.0007158079,0.00008392527,0.000560171,0.004404965,0.00002930787,0.001026474],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.151017,"threshold_uncertainty_score":0.4550688,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01258345314980986,"score_gpt":0.2529826262982793,"score_spread":0.2403991731484695,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}