{"id":"W4210620015","doi":"10.1200/jco.21.02377","title":"Sex Differences in Risk of Severe Adverse Events in Patients Receiving Immunotherapy, Targeted Therapy, or Chemotherapy in Cancer Clinical Trials","year":2022,"lang":"en","type":"article","venue":"Journal of Clinical Oncology","topic":"Cancer Immunotherapy and Biomarkers","field":"Medicine","cited_by":317,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"National Cancer Institute","keywords":"Adverse effect; Chemotherapy; Pharmacogenomics; Clinical trial; Drug; Cancer; Modalities; Cancer treatment","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.01924193,0.0002305113,0.0008453248,0.001067639,0.0003254126,0.00109014,0.0003024392,0.0003855219,0.002106113],"category_scores_gemma":[0.0447018,0.00015224,0.001362894,0.001883386,0.0004859985,0.0007497254,0.0005704168,0.0006162949,0.0001519314],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002159521,"about_ca_system_score_gemma":0.0004395661,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00034032,"about_ca_topic_score_gemma":0.0005642674,"domain_scores_codex":[0.9780361,0.01317245,0.004360006,0.001811565,0.002172384,0.0004473922],"domain_scores_gemma":[0.9135088,0.04217164,0.03938958,0.001954219,0.001460943,0.00151479],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.002296503,0.00002148268,0.9786195,0.0003603507,0.001131569,0.0001024706,0.0001018269,0.0001212036,0.0001294536,0.0002085033,0.0004475065,0.01645959],"study_design_scores_gemma":[0.0004625091,0.001018621,0.990115,0.000333205,0.001091429,0.001452711,0.0002154745,0.0008341321,0.0002511867,0.001142354,0.003063527,0.00001975115],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9184232,0.07124114,0.002139416,0.001766244,0.0001998642,0.0002057732,0.001724125,0.00003263788,0.004267603],"genre_scores_gemma":[0.9954928,0.002904277,0.0004106395,0.0004241758,0.0001578276,0.00009519462,0.0003424587,0.000008608088,0.0001640184],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01924193,"threshold_uncertainty_score":0.1017622,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1927373088180641,"score_gpt":0.4954685399841905,"score_spread":0.3027312311661263,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}