{"id":"W4210624082","doi":"10.1101/2022.01.31.478169","title":"Mechanistic insights into intramembrane proteolysis by <i>E. coli</i> site-2 protease homolog RseP","year":2022,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Bacterial Genetics and Biotechnology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Institute of Genetics; Institute for Protein Research, Osaka University; Life Science Center for Survival Dynamics Tsukuba Advanced Research Alliance; Japan Society for the Promotion of Science; Ministry of Education, Culture, Sports, Science and Technology; Keio University; Institute for Frontier Life and Medical Sciences, Kyoto University; University of Tsukuba; Japan Agency for Medical Research and Development","keywords":"Proteases; Transmembrane domain; Transmembrane protein; Proteolysis; Biology; Cleave; Biochemistry; Proteostasis; Biophysics; Cell biology; Membrane; Enzyme","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000213384,0.0003631939,0.000162502,0.0001129378,0.0001779493,0.0004511923,0.0003241678,0.0005543866,0.001503833],"category_scores_gemma":[0.0001687378,0.0001216044,0.000236575,0.00009611562,0.0002316113,0.0004437552,0.0001824564,0.0007669076,0.000461685],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002525147,"about_ca_system_score_gemma":0.0001524373,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002635693,"about_ca_topic_score_gemma":0.0001768584,"domain_scores_codex":[0.9999195,0.00001714361,0.0000046306,0.00001647357,0.00002112563,0.00002106911],"domain_scores_gemma":[0.9999244,0.00001707204,0.00002431596,0.000008748162,0.000008018278,0.00001739047],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003638561,0.00009784359,0.002472279,0.0001118279,0.00001942986,0.001424674,0.00007553732,0.001681141,0.9861984,0.003945425,0.0005166139,0.003092945],"study_design_scores_gemma":[0.00005044644,0.0001972952,0.007464836,0.00001702344,0.000022077,0.002898065,0.0002281324,0.01801319,0.9625731,0.002049149,0.006467706,0.00001903477],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9853663,0.001343586,0.009351882,0.0005294406,0.00003389277,0.00001671247,0.0002397372,0.0001502422,0.002968128],"genre_scores_gemma":[0.9942189,0.0004431729,0.003914219,0.0001275983,0.000009449479,0.00000786949,0.0002595117,0.00001367881,0.001005543],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001503833,"threshold_uncertainty_score":0.005030811,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005177470975785206,"score_gpt":0.1960182386534806,"score_spread":0.1908407676776954,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}