{"id":"W4210640163","doi":"10.3390/ph15020197","title":"Pyrazole and Triazole Derivatives as Mycobacterium tuberculosis UDP-Galactopyranose Inhibitors","year":2022,"lang":"en","type":"article","venue":"Pharmaceuticals","topic":"Carbohydrate Chemistry and Synthesis","field":"Chemistry","cited_by":12,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Saskatchewan","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Mycobacterium tuberculosis; Pyrazole; Tuberculosis; Chemistry; In vitro; Triazole; Mycobacterium; Enzyme; Microbiology; Stereochemistry; Biology; Biochemistry; Medicine; Pathology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0002972715,0.0003025974,0.0003629124,0.00005969733,0.0004195284,0.00008729393,0.0002498649,0.00009389994,0.01803236],"category_scores_gemma":[0.000189275,0.0003217106,0.0001620356,0.0002332132,0.0001874673,0.0001536937,0.0004274272,0.000516278,0.00004687434],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001205493,"about_ca_system_score_gemma":0.00006044039,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000188068,"about_ca_topic_score_gemma":3.104965e-7,"domain_scores_codex":[0.9981086,0.00007461611,0.0004102605,0.0005234958,0.0004097684,0.0004732263],"domain_scores_gemma":[0.9987965,0.0003889659,0.0001069399,0.000335771,0.0000385069,0.0003333051],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002159346,0.0002051293,0.002440332,0.0001613728,0.0001215039,0.0000520145,0.0005756835,0.000007429342,0.9913677,0.0001011589,0.000824507,0.003927252],"study_design_scores_gemma":[0.0009127192,0.00001489441,0.0001425599,0.00001500196,0.0001150095,0.00007526429,0.0008503305,0.000198315,0.9030713,0.0003436916,0.09389786,0.0003630572],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9721297,0.0009966368,0.000002907095,0.001726964,0.0001742719,0.0001067303,0.000153496,0.0001676793,0.02454158],"genre_scores_gemma":[0.9971403,0.0002336188,0.00003725975,0.0006143959,0.0002720841,0.0001818613,0.00005595732,0.00004707535,0.001417408],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.09307335,"threshold_uncertainty_score":0.9999235,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0239214145803929,"score_gpt":0.2937688469296767,"score_spread":0.2698474323492838,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}