{"id":"W4210650500","doi":"10.1001/jamaneurol.2021.5216","title":"Prevalence Estimates of Amyloid Abnormality Across the Alzheimer Disease Clinical Spectrum","year":2022,"lang":"en","type":"article","venue":"JAMA Neurology","topic":"Dementia and Cognitive Impairment Research","field":"Medicine","cited_by":288,"is_retracted":false,"has_abstract":true,"ca_institutions":"Montreal Neurological Institute and Hospital; Alzheimer Society of Canada; McGill University; Douglas Mental Health University Institute","funders":"Cliniques Universitaires Saint-Luc; National Institute on Aging; Faculty of Medicine and Health, University of Sydney; Healthy Aging Research Center; Sahlgrenska Akademin; Wydział Lekarski, Uniwersytet Jagielloński Collegium Medicum; University of California, San Francisco; Samsung; Genentech; Medizinische Fakultät der Albert-Ludwigs-Universität Freiburg; Université de Paris; Amsterdam Neuroscience; Sorbonne Université; Instituto de Investigación Marqués de Valdecilla; UK Dementia Research Institute; Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas; Shionogi; Akershus Universitetssykehus; Alzheimer Nederland; Région Normandie; National Institute of Neurological Disorders and Stroke; Universitatea de Medicină şi Farmacie \"Carol Davila\" Bucureşti; Institut National de la Santé et de la Recherche Médicale; H. Lundbeck A/S; Université Paris-Saclay; University of Texas at Dallas; Servier; Institut de Neurosciences des Systèmes; Siemens Healthineers; Novo Nordisk; Università degli Studi di Brescia; Uppsala Universitet; Instituto de Salud Carlos III; Universidad de Cantabria; Fondation pour la Recherche sur Alzheimer; Radboud Universitair Medisch Centrum; Göteborgs Universitet; Universität zu Köln; Irving Medical Center, Columbia University; Aristotle University of Thessaloniki; Chang Gung University; Sahlgrenska Universitetssjukhuset; Deutsches Zentrum für Neurodegenerative Erkrankungen; National and Kapodistrian University of Athens; Eisai; Leids Universitair Medisch Centrum; Brigham and Women's Hospital; Instytut Medycyny Doswiadczalnej i Klinicznej im. M. Mossakowskiego, Polskiej Akademii Nauk; Albert-Ludwigs-Universität Freiburg; Chang Gung Medical Foundation; Rheinische Friedrich-Wilhelms-Universität Bonn; Vrije Universiteit Brussel; Linköpings Universitet; Universiteit Antwerpen; Seoul National University Hospital; Università degli Studi di Genova; Kuopion Yliopistollinen Sairaala; Amsterdam University Medical Centers; Karolinska Institutet; Universidade de Coimbra; Örebro Universitet; Technische Universität München; Nederlandse Organisatie voor Wetenschappelijk Onderzoek; Imperial College London; King's College London; Gentofte Hospital; Lawrence Berkeley National Laboratory; European Regional Development Fund; Seoul National University; KU Leuven; University of Pittsburgh; Universiteit Maastricht; Université de Genève; Vrije Universiteit Amsterdam; Eli Lilly and Company; Radboud Universiteit; Universität Heidelberg; Università di Bologna; Alnylam Pharmaceuticals; Prothena; European Commission; Brown University; Newcastle University; Lunds Universitet; Institut de Recherches Servier; University of Sydney; Université de Lausanne; Massachusetts General Hospital; Uniwersytet Jagielloński Collegium Medicum; University College London; Avid Radiopharmaceuticals; Centre National de la Recherche Scientifique; Carl von Ossietzky Universität Oldenburg; Universitätsmedizin Göttingen; Lui Che Woo Institute of Innovative Medicine; Université de Caen Normandie; Turun Yliopisto; Assistance publique-Hôpitaux de Paris; Biogen; Rigshospitalet; Celgene; Sungkyunkwan University; Faculty of Medicine, McGill University; Univerzita Karlova v Praze; McGill University; Emory University; Council of Scientific and Industrial Research, India; Norges Teknisk-Naturvitenskapelige Universitet; Alzheimer's Association; Thomas Jefferson University; Weill Cornell Medical College; University of Pennsylvania; Aarhus Universitet; ZonMw; Postgraduate Institute of Medical Education and Research, Chandigarh; Perelman School of Medicine, University of Pennsylvania; McLean Hospital; Universitätsklinikum Köln; National Institutes of Health; Chinese University of Hong Kong; Itä-Suomen Yliopisto","keywords":"Dementia; Biomarker; Cognition; Abnormality; Medicine; Cognitive decline; Disease; Alzheimer's disease; Cohort; Internal medicine; Cognitive test; Psychology; Oncology; Pathology; Psychiatry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.02152495,0.0006652977,0.001112349,0.004090715,0.0003708015,0.001303542,0.001026317,0.0009235611,0.001177514],"category_scores_gemma":[0.03635973,0.0006194882,0.001938736,0.002870226,0.000740646,0.0009969358,0.001451815,0.0006316967,0.0002567711],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000338692,"about_ca_system_score_gemma":0.0003224301,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002183739,"about_ca_topic_score_gemma":0.001731655,"domain_scores_codex":[0.9887297,0.005367412,0.001615971,0.002815971,0.001283486,0.000187603],"domain_scores_gemma":[0.9733181,0.009641855,0.01039708,0.003918289,0.002355526,0.0003691743],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0004659637,0.00002593544,0.9890118,0.0001993042,0.003179117,0.00004638831,0.0001388929,0.0004259119,0.0003215678,0.0002010655,0.000401055,0.005583074],"study_design_scores_gemma":[0.00006502067,0.0002472504,0.9924584,0.0001204628,0.002037526,0.0004935439,0.000172514,0.002111944,0.0002490048,0.0008142111,0.001204671,0.00002548911],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9537041,0.01232485,0.021252,0.0003775524,0.00008952429,0.0002457343,0.009809173,0.000149449,0.002047653],"genre_scores_gemma":[0.9910485,0.001003242,0.003784982,0.0001170515,0.00006974005,0.000219631,0.003516581,0.00001791368,0.0002224201],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02152495,"threshold_uncertainty_score":0.1138362,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04009503923384122,"score_gpt":0.3861550673669393,"score_spread":0.3460600281330981,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). 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