{"id":"W4210650500","doi":"10.1001/jamaneurol.2021.5216","title":"Prevalence Estimates of Amyloid Abnormality Across the Alzheimer Disease Clinical Spectrum","year":2022,"lang":"en","type":"article","venue":"JAMA Neurology","topic":"Dementia and Cognitive Impairment Research","field":"Medicine","cited_by":288,"is_retracted":false,"has_abstract":true,"ca_institutions":"Montreal Neurological Institute and Hospital; Alzheimer Society of Canada; McGill University; Douglas Mental Health University Institute","funders":"Cliniques Universitaires Saint-Luc; National Institute on Aging; Faculty of Medicine and Health, University of Sydney; Healthy Aging Research Center; Sahlgrenska Akademin; Wydział Lekarski, Uniwersytet Jagielloński Collegium Medicum; University of California, San Francisco; Samsung; Genentech; Medizinische Fakultät der Albert-Ludwigs-Universität Freiburg; Université de Paris; Amsterdam Neuroscience; Sorbonne Université; Instituto de Investigación Marqués de Valdecilla; UK Dementia Research Institute; Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas; Shionogi; Akershus Universitetssykehus; Alzheimer Nederland; Région Normandie; National Institute of Neurological Disorders and Stroke; Universitatea de Medicină şi Farmacie \"Carol Davila\" Bucureşti; Institut National de la Santé et de la Recherche Médicale; H. Lundbeck A/S; Université Paris-Saclay; University of Texas at Dallas; Servier; Institut de Neurosciences des Systèmes; Siemens Healthineers; Novo Nordisk; Università degli Studi di Brescia; Uppsala Universitet; Instituto de Salud Carlos III; Universidad de Cantabria; Fondation pour la Recherche sur Alzheimer; Radboud Universitair Medisch Centrum; Göteborgs Universitet; Universität zu Köln; Irving Medical Center, Columbia University; Aristotle University of Thessaloniki; Chang Gung University; Sahlgrenska Universitetssjukhuset; Deutsches Zentrum für Neurodegenerative Erkrankungen; National and Kapodistrian University of Athens; Eisai; Leids Universitair Medisch Centrum; Brigham and Women's Hospital; Instytut Medycyny Doswiadczalnej i Klinicznej im. M. Mossakowskiego, Polskiej Akademii Nauk; Albert-Ludwigs-Universität Freiburg; Chang Gung Medical Foundation; Rheinische Friedrich-Wilhelms-Universität Bonn; Vrije Universiteit Brussel; Linköpings Universitet; Universiteit Antwerpen; Seoul National University Hospital; Università degli Studi di Genova; Kuopion Yliopistollinen Sairaala; Amsterdam University Medical Centers; Karolinska Institutet; Universidade de Coimbra; Örebro Universitet; Technische Universität München; Nederlandse Organisatie voor Wetenschappelijk Onderzoek; Imperial College London; King's College London; Gentofte Hospital; Lawrence Berkeley National Laboratory; European Regional Development Fund; Seoul National University; KU Leuven; University of Pittsburgh; Universiteit Maastricht; Université de Genève; Vrije Universiteit Amsterdam; Eli Lilly and Company; Radboud Universiteit; Universität Heidelberg; Università di Bologna; Alnylam Pharmaceuticals; Prothena; European Commission; Brown University; Newcastle University; Lunds Universitet; Institut de Recherches Servier; University of Sydney; Université de Lausanne; Massachusetts General Hospital; Uniwersytet Jagielloński Collegium Medicum; University College London; Avid Radiopharmaceuticals; Centre National de la Recherche Scientifique; Carl von Ossietzky Universität Oldenburg; Universitätsmedizin Göttingen; Lui Che Woo Institute of Innovative Medicine; Université de Caen Normandie; Turun Yliopisto; Assistance publique-Hôpitaux de Paris; Biogen; Rigshospitalet; Celgene; Sungkyunkwan University; Faculty of Medicine, McGill University; Univerzita Karlova v Praze; McGill University; Emory University; Council of Scientific and Industrial Research, India; Norges Teknisk-Naturvitenskapelige Universitet; Alzheimer's Association; Thomas Jefferson University; Weill Cornell Medical College; University of Pennsylvania; Aarhus Universitet; ZonMw; Postgraduate Institute of Medical Education and Research, Chandigarh; Perelman School of Medicine, University of Pennsylvania; McLean Hospital; Universitätsklinikum Köln; National Institutes of Health; Chinese University of Hong Kong; Itä-Suomen Yliopisto","keywords":"Dementia; Biomarker; Cognition; Abnormality; Medicine; Cognitive decline; Disease; Alzheimer's disease; Cohort; Internal medicine; Cognitive test; Psychology; Oncology; Pathology; Psychiatry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.001317603,0.00010085,0.0002204385,0.00003202356,0.0002092166,0.00001297835,0.000277075,0.00004447219,0.001815346],"category_scores_gemma":[0.0004000927,0.00007111554,0.0001534384,0.0001565678,0.0005061039,0.00005071711,0.0005492574,0.000805532,0.00003422055],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000006464015,"about_ca_system_score_gemma":0.0001211806,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000288443,"about_ca_topic_score_gemma":0.000002313457,"domain_scores_codex":[0.9979187,0.0005932243,0.0003541078,0.0003183789,0.0004260344,0.0003895758],"domain_scores_gemma":[0.9986823,0.0005685474,0.0001107066,0.0004138825,0.00006515553,0.0001593636],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.002656765,0.0005668877,0.9910876,0.00004869193,0.00008575714,0.0003607224,0.00006246951,0.00001156835,0.00006738408,0.0001460919,0.001229642,0.00367645],"study_design_scores_gemma":[0.001233236,0.001901751,0.9901057,0.000003387145,0.0001878301,0.0001160435,0.00003287697,0.0007558073,0.0003195216,0.0005447107,0.004744374,0.00005479432],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9759741,0.0005499013,0.00002210205,0.02172261,0.0002240383,0.0005003284,0.00007175604,0.00002854019,0.0009066511],"genre_scores_gemma":[0.9933089,0.0001101503,0.00001345986,0.006067005,0.0001495827,0.0001017356,0.00001470159,0.00001215923,0.0002223196],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01733482,"threshold_uncertainty_score":0.9990971,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04009503923384122,"score_gpt":0.3861550673669393,"score_spread":0.3460600281330981,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). 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