{"id":"W4210660522","doi":"10.1111/mec.16377","title":"The importance of alternative splicing in adaptive evolution","year":2022,"lang":"en","type":"article","venue":"Molecular Ecology","topic":"RNA Research and Splicing","field":"Biochemistry, Genetics and Molecular Biology","cited_by":137,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"Karl-Franzens-Universität Graz; Medizinische Universität Graz; University of Bern","keywords":"Biology; Adaptive evolution; Evolutionary biology; Alternative splicing; Computational biology; Genetics; Gene; Exon","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004305043,0.00006976196,0.00009943098,0.00005239054,0.000140444,0.000003739593,0.0002484801,0.00003724761,0.00001657466],"category_scores_gemma":[0.0001161977,0.00006247155,0.00005281394,0.0001382613,0.00008762981,0.000001608227,0.0002997543,0.0001537349,0.000001367961],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000848467,"about_ca_system_score_gemma":0.0001014774,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001167648,"about_ca_topic_score_gemma":0.0007886523,"domain_scores_codex":[0.9989854,0.0002310609,0.0001777628,0.000211685,0.0001346042,0.0002595434],"domain_scores_gemma":[0.9995789,0.00003093434,0.0000900554,0.0002259964,0.00004501359,0.00002913588],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000235416,0.00005615315,0.07457038,0.000003223297,0.00004721051,0.00005349064,0.00004216767,0.005722934,0.9113097,0.0072261,0.0001939639,0.0005392888],"study_design_scores_gemma":[0.004428379,0.006322738,0.3194533,0.00001674857,0.00003168202,0.000171925,0.003593541,0.02210404,0.6196542,0.0140416,0.009410514,0.0007712923],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9966446,0.0006551439,0.001496556,0.0002599473,0.0000753392,0.0001959209,0.000006097262,0.00000242654,0.0006639314],"genre_scores_gemma":[0.9992446,0.00002706366,0.0001055642,0.0001624881,0.00001918518,0.000098948,0.00001272186,0.00001014883,0.0003192272],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2916554,"threshold_uncertainty_score":0.2547516,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008369145329454352,"score_gpt":0.2615326156689902,"score_spread":0.2531634703395358,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}