{"id":"W4210665241","doi":"10.1038/s41586-022-04474-x","title":"Altered TMPRSS2 usage by SARS-CoV-2 Omicron impacts infectivity and fusogenicity","year":2022,"lang":"en","type":"article","venue":"Nature","topic":"SARS-CoV-2 and COVID-19 Research","field":"Medicine","cited_by":1167,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Strategic International Collaborative Research Program; Core Research for Evolutional Science and Technology; Institute of Genetics; National Institute of Allergy and Infectious Diseases; Research Institute for Microbial Diseases, Osaka University; Japan Society for the Promotion of Science; South African Medical Research Council; National Institutes of Health; Rosetrees Trust; NIHR BioResource; University of Cambridge; Academy of Medical Sciences; Medical Research Council; Department of Health and Social Care; NHS Blood and Transplant; National Institute for Health and Care Research; Fast Grants; Engineering and Physical Sciences Research Council; UK Research and Innovation; Tokyo Biochemical Research Foundation; Wellcome Trust; European Association for the Study of the Liver; National Institute of General Medical Sciences; Burroughs Wellcome Fund; Howard Hughes Medical Institute; Mitsubishi Foundation; Takeda Science Foundation; Newcastle University; Japan Agency for Medical Research and Development; Bill and Melinda Gates Foundation","keywords":"Virology; Infectivity; Virus; Viral entry; Biology; Chemistry; Viral replication; Molecular biology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007876055,0.0002526004,0.0001606552,0.00009913807,0.0001005325,0.0002167128,0.00009055475,0.0002359414,0.001286666],"category_scores_gemma":[0.0001274979,0.00009186327,0.0002306118,0.00008738284,0.0001307041,0.0001197433,0.0001263919,0.0003025243,0.0002796855],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002520634,"about_ca_system_score_gemma":0.0001149942,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001023719,"about_ca_topic_score_gemma":0.001068356,"domain_scores_codex":[0.9998974,0.00001828138,0.00000980684,0.00001397911,0.00002912321,0.00003154434],"domain_scores_gemma":[0.999947,0.00001085502,0.00001653605,0.000006094766,0.000006662018,0.00001285447],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008628895,0.00001526843,0.0004379716,0.000006388422,0.000002156974,0.00005090043,0.000005053812,0.000048165,0.9990317,0.00002061205,0.00001772537,0.0002777062],"study_design_scores_gemma":[0.00001894802,0.0007462482,0.02325155,0.00000629369,0.0000161814,0.0009796353,0.00007816673,0.001827165,0.9717143,0.00006354389,0.001288848,0.00000908039],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9991961,0.00008846545,0.0001729386,0.0000165099,0.000004671336,0.000004480588,0.0001550464,0.000007434289,0.0003543753],"genre_scores_gemma":[0.9991369,0.00005567406,0.0001710591,0.00002144104,0.000001759622,0.00000460681,0.0002280304,0.000004771476,0.0003757689],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001286666,"threshold_uncertainty_score":0.00430429,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02298390944803079,"score_gpt":0.3485386215219114,"score_spread":0.3255547120738806,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}