{"id":"W4210671378","doi":"10.1002/pro.4279","title":"Structures of plasmepsin X from <i>Plasmodium falciparum</i> reveal a novel inactivation mechanism of the zymogen and molecular basis for binding of inhibitors in mature enzyme","year":2022,"lang":"en","type":"article","venue":"Protein Science","topic":"Malaria Research and Control","field":"Medicine","cited_by":27,"is_retracted":false,"has_abstract":true,"ca_institutions":"Agriculture and Agri-Food Canada; University of British Columbia","funders":"National Institute of Allergy and Infectious Diseases; National Cancer Institute; Indian Institute of Technology Bombay; Michigan Technology Tri-Corridor; Office of Science; Natural Sciences and Engineering Research Council of Canada; Purdue University Center for Cancer Research; Argonne National Laboratory; U.S. Department of Energy; Department of Biotechnology, Ministry of Science and Technology, India; Industrial Research and Consultancy Centre; National Institutes of Health; Michigan Economic Development Corporation; U.S. Department of Health and Human Services","keywords":"Zymogen; Plasmodium falciparum; Proteases; Biochemistry; Protease; Enzyme; Biology; Cleavage (geology); Pepsin; Chemistry; Malaria","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007813297,0.00007083511,0.0001996781,0.0001967641,0.0000880848,0.000007541138,0.0002459914,0.00003643786,0.00001473094],"category_scores_gemma":[0.000723178,0.00005187002,0.00004324845,0.0006775331,0.0001920091,0.00007789559,0.0002061672,0.0001673127,2.624326e-8],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006957971,"about_ca_system_score_gemma":0.0003366855,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004105708,"about_ca_topic_score_gemma":0.00001336475,"domain_scores_codex":[0.9986365,0.00004921531,0.0002340187,0.0002170193,0.0006848773,0.0001784148],"domain_scores_gemma":[0.9993762,0.00007318128,0.0001927674,0.0002010717,0.0001099626,0.00004675446],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003816086,0.00004454929,0.0003812897,0.00007818628,0.000008390047,7.070678e-7,0.0003184366,0.00004523291,0.9878007,0.01052423,0.000005171938,0.0004115191],"study_design_scores_gemma":[0.001150002,0.0002423299,0.003165581,0.00009972165,0.0000113584,0.000002208269,0.0003418926,0.001790152,0.9900547,0.003082691,0.00001507843,0.00004433096],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9957643,0.00007820716,0.001367762,0.001131224,0.00004050626,0.001413782,0.0001529762,0.000003024576,0.00004825094],"genre_scores_gemma":[0.9958818,7.923369e-7,0.003895423,0.00004183319,0.000009140747,0.0001440792,0.000002668191,0.000005685496,0.00001857892],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.007441536,"threshold_uncertainty_score":0.2115198,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01497548269105962,"score_gpt":0.2607688709368252,"score_spread":0.2457933882457656,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}