{"id":"W4210671378","doi":"10.1002/pro.4279","title":"Structures of plasmepsin X from <i>Plasmodium falciparum</i> reveal a novel inactivation mechanism of the zymogen and molecular basis for binding of inhibitors in mature enzyme","year":2022,"lang":"en","type":"article","venue":"Protein Science","topic":"Malaria Research and Control","field":"Medicine","cited_by":27,"is_retracted":false,"has_abstract":true,"ca_institutions":"Agriculture and Agri-Food Canada; University of British Columbia","funders":"National Institute of Allergy and Infectious Diseases; National Cancer Institute; Indian Institute of Technology Bombay; Michigan Technology Tri-Corridor; Office of Science; Natural Sciences and Engineering Research Council of Canada; Purdue University Center for Cancer Research; Argonne National Laboratory; U.S. Department of Energy; Department of Biotechnology, Ministry of Science and Technology, India; Industrial Research and Consultancy Centre; National Institutes of Health; Michigan Economic Development Corporation; U.S. Department of Health and Human Services","keywords":"Zymogen; Plasmodium falciparum; Proteases; Biochemistry; Protease; Enzyme; Biology; Cleavage (geology); Pepsin; Chemistry; Malaria","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00006464514,0.0002350574,0.0001460152,0.00005944769,0.0001418173,0.0001984792,0.0002242057,0.0003107989,0.001164123],"category_scores_gemma":[0.0001238809,0.0001616085,0.0001705282,0.00008816225,0.000167352,0.0002757935,0.0001415033,0.0007282922,0.0001312068],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002771092,"about_ca_system_score_gemma":0.0001955557,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009706199,"about_ca_topic_score_gemma":0.0007678936,"domain_scores_codex":[0.9999696,0.000004499516,0.000001730122,0.000005946152,0.000009498101,0.000008620797],"domain_scores_gemma":[0.9999512,0.00001082845,0.00001930025,0.000002124215,0.000005132491,0.00001139205],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0007658772,0.0001148811,0.004371401,0.0002425655,0.00004804535,0.002221165,0.0002492031,0.003811339,0.9765751,0.002322712,0.001511406,0.007766274],"study_design_scores_gemma":[0.000251775,0.001172627,0.05585745,0.0000494095,0.00009616228,0.004814287,0.0003796718,0.03630481,0.876658,0.001594327,0.02275607,0.00006545569],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9935809,0.001083296,0.002691016,0.0002784664,0.00001801251,0.0000189382,0.0002208962,0.00004358478,0.002064857],"genre_scores_gemma":[0.9928842,0.0007620354,0.003762291,0.0001045103,0.000007693084,0.00001017278,0.0008987007,0.00001008304,0.001560502],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001164123,"threshold_uncertainty_score":0.003894329,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01497548269105962,"score_gpt":0.2607688709368252,"score_spread":0.2457933882457656,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}