{"id":"W4210678102","doi":"10.3390/cells11030545","title":"Prevention of Lipotoxicity in Pancreatic Islets with Gammahydroxybutyrate","year":2022,"lang":"en","type":"article","venue":"Cells","topic":"Diet and metabolism studies","field":"Medicine","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"Toronto General Hospital; University of Waterloo; University of Toronto","funders":"University of Toronto; Jazz Pharmaceuticals","keywords":"Lipotoxicity; Oxidative stress; Internal medicine; Endocrinology; Diabetes mellitus; Pancreatic islets; Insulin; Islet; Antioxidant; Reactive oxygen species; Type 2 diabetes; Chemistry; Biology; Medicine; Insulin resistance; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001546548,0.00006166285,0.0002355206,0.00006841077,0.00002971972,0.000001555623,0.00003538092,0.0000119051,0.0002036248],"category_scores_gemma":[0.000009177858,0.00004933215,0.00003663946,0.0001788842,0.00003150988,0.00002164875,0.00004356469,0.00009091102,0.000006360452],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002213273,"about_ca_system_score_gemma":0.00004032179,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003548406,"about_ca_topic_score_gemma":0.00001020069,"domain_scores_codex":[0.9994431,0.00003880423,0.0001373737,0.0001075871,0.000160066,0.0001130862],"domain_scores_gemma":[0.9997565,0.00001739149,0.00005984357,0.0001198657,0.00002018294,0.00002617525],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.001434218,0.002224752,0.1391244,0.0007659594,0.0002979727,0.0001912926,0.006527859,0.0004439836,0.8346909,0.0006066473,0.004131918,0.009560055],"study_design_scores_gemma":[0.00819022,0.00260523,0.4857062,0.000341678,0.0005915006,0.00002256249,0.003098958,0.0003196664,0.45983,0.0008297324,0.03807086,0.0003933798],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.98895,0.0004835296,0.0000224602,0.00008432434,0.00009467685,0.0002694424,0.000004062808,0.00001169041,0.01007984],"genre_scores_gemma":[0.9925025,0.0001001718,0.0002217803,0.00006877074,0.00002578316,0.00004583227,0.000004973627,0.000007989067,0.00702221],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3748609,"threshold_uncertainty_score":0.2229549,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01348597831747396,"score_gpt":0.2469299730486404,"score_spread":0.2334439947311664,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}