{"id":"W4210678102","doi":"10.3390/cells11030545","title":"Prevention of Lipotoxicity in Pancreatic Islets with Gammahydroxybutyrate","year":2022,"lang":"en","type":"article","venue":"Cells","topic":"Diet and metabolism studies","field":"Medicine","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"Toronto General Hospital; University of Waterloo; University of Toronto","funders":"University of Toronto; Jazz Pharmaceuticals","keywords":"Lipotoxicity; Oxidative stress; Internal medicine; Endocrinology; Diabetes mellitus; Pancreatic islets; Insulin; Islet; Antioxidant; Reactive oxygen species; Type 2 diabetes; Chemistry; Biology; Medicine; Insulin resistance; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002725958,0.0005543359,0.0004498246,0.0003007445,0.0001896451,0.0003568291,0.0003047556,0.0003652812,0.001137071],"category_scores_gemma":[0.0001870697,0.000231909,0.0003402084,0.0002395555,0.0003090573,0.0003110948,0.0002506282,0.0008015617,0.0002997669],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001040629,"about_ca_system_score_gemma":0.0003192498,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005772809,"about_ca_topic_score_gemma":0.0007440654,"domain_scores_codex":[0.9998993,0.00002229698,0.00001172826,0.00001906349,0.00001810681,0.00002953788],"domain_scores_gemma":[0.9998165,0.00002367303,0.00005142889,0.00003125934,0.00001919475,0.00005800283],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001974868,0.0002970155,0.0002943417,0.00009961551,0.00001941822,0.00005056763,0.00002558126,0.00009395963,0.9935178,0.00006094358,0.00003204721,0.00353391],"study_design_scores_gemma":[0.0004355422,0.006768003,0.005101843,0.00004269147,0.00005768696,0.0001625103,0.00004875119,0.0003150582,0.9848914,0.0000780605,0.002090815,0.000007580729],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9931208,0.003609265,0.001797309,0.0001732768,0.00009096472,0.0000692274,0.0001784743,0.00007282961,0.000887766],"genre_scores_gemma":[0.9912568,0.003505085,0.002757655,0.000130259,0.0000420163,0.00006468624,0.0003334774,0.00003371687,0.001876292],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001137071,"threshold_uncertainty_score":0.003803909,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01348597831747396,"score_gpt":0.2469299730486404,"score_spread":0.2334439947311664,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}