{"id":"W4210682873","doi":"10.3389/fmolb.2021.787368","title":"Molecular Architecture of the Antiophidic Protein DM64 and its Binding Specificity to Myotoxin II From Bothrops asper Venom","year":2022,"lang":"en","type":"article","venue":"Frontiers in Molecular Biosciences","topic":"Venomous Animal Envenomation and Studies","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Lethbridge","funders":"National Institute of General Medical Sciences; National Cancer Institute; University of Texas Health Science Center at San Antonio; Conselho Nacional de Desenvolvimento Científico e Tecnológico; Centro Nacional de Pesquisa em Energia e Materiais; National Institutes of Health; Fundação Oswaldo Cruz; Fundação Carlos Chagas Filho de Amparo à Pesquisa do Estado do Rio de Janeiro; Laboratório Nacional de Luz Síncrotron; Royal Society of Tropical Medicine and Hygiene; Wellcome Trust; Ministério da Ciência, Tecnologia, Inovações e Comunicações; National Science Foundation","keywords":"Venom; Myotoxin; Bothrops; Biology; Scorpion; Snake venom; Computational biology; Zoology; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00004625734,0.000246957,0.0001374584,0.0001644876,0.0001685635,0.0003276771,0.0003014202,0.0002208427,0.0007019399],"category_scores_gemma":[0.00009930705,0.0001543787,0.0002324037,0.0001183466,0.0001629322,0.0001441423,0.0001614833,0.0003278449,0.0002626231],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004637261,"about_ca_system_score_gemma":0.0001897295,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001277772,"about_ca_topic_score_gemma":0.0008385418,"domain_scores_codex":[0.9999673,0.000004213903,0.000002194487,0.000009770055,0.000008943892,0.00000755029],"domain_scores_gemma":[0.9999546,0.000005617311,0.00001636859,0.000002893991,0.00000596282,0.00001467093],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002239116,0.00006345069,0.002904616,0.00005085649,0.00002025711,0.0005356589,0.00007835375,0.002701512,0.9909683,0.0006512586,0.0001013009,0.001700542],"study_design_scores_gemma":[0.000163426,0.001115681,0.1390117,0.00006828889,0.0001756292,0.002900786,0.000520307,0.171861,0.6714585,0.001897126,0.01075827,0.00006927978],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9980468,0.0002688309,0.0009718899,0.00003693512,0.00000345719,0.00000775837,0.00005929324,0.00001601127,0.0005890151],"genre_scores_gemma":[0.9978053,0.0002120059,0.0008841138,0.00003259561,0.000003644574,0.000007213904,0.0002739155,0.000005860791,0.0007752893],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001277772,"threshold_uncertainty_score":0.003364563,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006044401816682702,"score_gpt":0.2094650068725731,"score_spread":0.2034206050558904,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}