{"id":"W4210682873","doi":"10.3389/fmolb.2021.787368","title":"Molecular Architecture of the Antiophidic Protein DM64 and its Binding Specificity to Myotoxin II From Bothrops asper Venom","year":2022,"lang":"en","type":"article","venue":"Frontiers in Molecular Biosciences","topic":"Venomous Animal Envenomation and Studies","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Lethbridge","funders":"National Institute of General Medical Sciences; National Cancer Institute; University of Texas Health Science Center at San Antonio; Conselho Nacional de Desenvolvimento Científico e Tecnológico; Centro Nacional de Pesquisa em Energia e Materiais; National Institutes of Health; Fundação Oswaldo Cruz; Fundação Carlos Chagas Filho de Amparo à Pesquisa do Estado do Rio de Janeiro; Laboratório Nacional de Luz Síncrotron; Royal Society of Tropical Medicine and Hygiene; Wellcome Trust; Ministério da Ciência, Tecnologia, Inovações e Comunicações; National Science Foundation","keywords":"Venom; Myotoxin; Bothrops; Biology; Scorpion; Snake venom; Computational biology; Zoology; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00024542,0.0001553792,0.0001962351,0.0001212343,0.0003804902,0.0000216715,0.0004667109,0.00005361561,0.00001345291],"category_scores_gemma":[0.00008451008,0.0001294186,0.00008427306,0.0004623524,0.0001979993,0.000004521946,0.0007139653,0.0001403358,4.790799e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002991316,"about_ca_system_score_gemma":0.00006601829,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004073559,"about_ca_topic_score_gemma":0.00001755326,"domain_scores_codex":[0.998583,0.0001609681,0.0002218819,0.0004606616,0.0003306986,0.0002427691],"domain_scores_gemma":[0.9995611,0.000003190554,0.0001053256,0.0002453359,0.0000255011,0.00005950232],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003254462,0.00005947911,0.002416468,0.000007850658,0.00002491901,0.000008022696,0.0003290677,0.0008915827,0.9953823,0.0002203451,0.0001767524,0.000450674],"study_design_scores_gemma":[0.0003721817,0.0006077373,0.007199266,0.00002976873,0.00001669467,0.000006935077,0.001177595,0.0002990068,0.9792849,0.0006430735,0.01006071,0.0003021621],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9913054,0.003146142,0.003533519,0.0009394252,0.0002696903,0.0004709686,0.00007997633,0.00000621761,0.0002486969],"genre_scores_gemma":[0.99619,0.00002951281,0.003257284,0.0003145132,0.00002327607,0.00004894048,0.000009555051,0.00001311157,0.0001137836],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01609743,"threshold_uncertainty_score":0.5277539,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006044401816682702,"score_gpt":0.2094650068725731,"score_spread":0.2034206050558904,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}