{"id":"W4210701219","doi":"10.3389/fmolb.2022.831091","title":"Genetic Modifications That Expand Oncolytic Virus Potency","year":2022,"lang":"en","type":"review","venue":"Frontiers in Molecular Biosciences","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":40,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Li Ka Shing Institute of Virology, University of Alberta; Canada Research Chairs; Canadian Cancer Society Research Institute; Canadian Institutes of Health Research; Cancer Research Society; University of Alberta; Faculty of Medicine and Dentistry, University of Alberta; Cancer Research Institute","keywords":"Oncolytic virus; Tumor microenvironment; Virus; Metastasis; Cancer; Biology; Cancer research; Cancer therapy; Virotherapy; Cancer cell; Virology; Medicine; Tumor cells; Immunology; Computational biology; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0006817141,0.0005257924,0.0008647,0.0006582809,0.0002964909,0.0001178127,0.001990724,0.0003617875,0.0001077655],"category_scores_gemma":[0.0001325247,0.0004916163,0.0004885228,0.001203146,0.0005113794,0.000008089931,0.000446752,0.000464917,0.00001665571],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002041427,"about_ca_system_score_gemma":0.001271669,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000497309,"about_ca_topic_score_gemma":0.00007369446,"domain_scores_codex":[0.9958892,0.000689012,0.0005573415,0.001319742,0.0007932168,0.0007514924],"domain_scores_gemma":[0.9982768,0.0000239955,0.0002836239,0.001182974,0.00003557629,0.000197012],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00006158226,0.0001973994,0.00004938938,0.0006365332,0.0001353927,0.00009036917,0.00004919636,0.0001165633,0.004982455,0.000009273771,0.003069731,0.9906021],"study_design_scores_gemma":[0.0002327652,0.0008845432,0.000007919504,0.0002324899,0.0001058405,0.00003178922,0.0001269273,0.00006434367,0.002278872,0.0001153315,0.9952664,0.0006527455],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0008850522,0.9922502,0.003983102,0.00003342632,0.0008706758,0.001120019,0.0001104696,0.00002029281,0.0007267552],"genre_scores_gemma":[0.0002351762,0.9938048,0.004135701,0.0001272365,0.00009613384,0.0006417272,0.0001788846,0.00008187664,0.0006984447],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9921967,"threshold_uncertainty_score":0.9997535,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04782522189619379,"score_gpt":0.3423937461381165,"score_spread":0.2945685242419227,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}