{"id":"W4210701219","doi":"10.3389/fmolb.2022.831091","title":"Genetic Modifications That Expand Oncolytic Virus Potency","year":2022,"lang":"en","type":"review","venue":"Frontiers in Molecular Biosciences","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":40,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Li Ka Shing Institute of Virology, University of Alberta; Canada Research Chairs; Canadian Cancer Society Research Institute; Canadian Institutes of Health Research; Cancer Research Society; University of Alberta; Faculty of Medicine and Dentistry, University of Alberta; Cancer Research Institute","keywords":"Oncolytic virus; Tumor microenvironment; Virus; Metastasis; Cancer; Biology; Cancer research; Cancer therapy; Virotherapy; Cancer cell; Virology; Medicine; Tumor cells; Immunology; Computational biology; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002941273,0.0005604677,0.0005775592,0.001110755,0.000122237,0.0005545727,0.0004388985,0.0006861374,0.001840606],"category_scores_gemma":[0.0003022905,0.0002425435,0.000381186,0.0006961563,0.0003202372,0.000710031,0.0003674505,0.001374829,0.001106947],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000487219,"about_ca_system_score_gemma":0.0003604392,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005443995,"about_ca_topic_score_gemma":0.0006766891,"domain_scores_codex":[0.9998869,0.00001561342,0.00001103518,0.00002360654,0.00004742299,0.00001539326],"domain_scores_gemma":[0.9999275,0.00003369225,0.00001180872,0.000004254242,0.00001742681,0.000005365838],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.000121621,0.0001127865,0.0002116204,0.01337055,0.00009131273,0.0003273161,0.00008953959,0.001286646,0.0988104,0.02007404,0.01202666,0.8534775],"study_design_scores_gemma":[0.00002015319,0.0001602803,0.0004690139,0.0007548602,0.00006214107,0.0009310485,0.00002246374,0.0001872238,0.02371155,0.001845404,0.9718168,0.00001903393],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.002704298,0.9863869,0.002200535,0.0003060664,0.0003969975,0.00003020628,0.00007852289,0.00004406702,0.007852391],"genre_scores_gemma":[0.0102289,0.984426,0.001560068,0.0002624612,0.000086824,0.00003161935,0.0001207456,0.000009911532,0.003273535],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.001840606,"threshold_uncertainty_score":0.006157517,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04782522189619379,"score_gpt":0.3423937461381165,"score_spread":0.2945685242419227,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}