{"id":"W4210701828","doi":"10.1242/jeb.243293","title":"Blending physiology and RNAseq to provide new insights into regulation of epithelial transport: switching between ion secretion and reabsorption","year":2022,"lang":"en","type":"review","venue":"Journal of Experimental Biology","topic":"Neurobiology and Insect Physiology Research","field":"Neuroscience","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University","funders":"","keywords":"Reabsorption; Malpighian tubule system; Tubule; Cell biology; Hindgut; Biology; Lumen (anatomy); Apical membrane; Ion transporter; Ion channel; Mechanosensation; Internal medicine; Nephron; Chemistry; Endocrinology; Epithelium; Anatomy; Kidney; Receptor; Biochemistry; Midgut","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00290668,0.001376841,0.002058514,0.001196414,0.0004173514,0.002633893,0.000977553,0.001158838,0.003457408],"category_scores_gemma":[0.001452074,0.0006481718,0.001468473,0.00139877,0.001561475,0.002922904,0.001099203,0.003918823,0.002420967],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006886639,"about_ca_system_score_gemma":0.001066023,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003171119,"about_ca_topic_score_gemma":0.0004792739,"domain_scores_codex":[0.9985346,0.0002984948,0.0001387502,0.0004083439,0.0005171776,0.0001026436],"domain_scores_gemma":[0.9991597,0.0003953375,0.000086211,0.0001137178,0.0001926268,0.00005238985],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0002332735,0.00005629224,0.001160968,0.008805034,0.00043861,0.0007546457,0.0004963804,0.001793606,0.6189355,0.02405849,0.01018704,0.3330801],"study_design_scores_gemma":[0.00005732035,0.00057785,0.002922602,0.0005649157,0.0003640744,0.00203633,0.0002364166,0.003731951,0.2498602,0.01990649,0.7195498,0.0001921315],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.01840284,0.4919125,0.4519652,0.006609767,0.007000893,0.0002099162,0.002177182,0.005913957,0.01580758],"genre_scores_gemma":[0.113022,0.5251516,0.3182777,0.008632977,0.00450201,0.0008256889,0.004931187,0.002698431,0.02195851],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.003457408,"threshold_uncertainty_score":0.01537216,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0704459286153449,"score_gpt":0.3654593082417005,"score_spread":0.2950133796263555,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}