{"id":"W4210712234","doi":"10.1002/alz.052993","title":"Clinical value of CSF tau, p‐tau181, neurogranin and neurofilaments in familial frontotemporal lobar degeneration","year":2021,"lang":"en","type":"article","venue":"Alzheimer s & Dementia","topic":"Amyotrophic Lateral Sclerosis Research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; University of British Columbia","funders":"","keywords":"Frontotemporal lobar degeneration; Neurogranin; Frontotemporal dementia; Biomarker; Internal medicine; Oncology; Medicine; Psychology; Tau protein; Gastroenterology; Dementia; Pathology; Alzheimer's disease; Endocrinology; Disease; Biology; Genetics; Phosphorylation","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006606294,0.0005063897,0.0003681754,0.0007956575,0.0003470296,0.000504007,0.00027361,0.0005673049,0.0009400711],"category_scores_gemma":[0.002606738,0.0002011336,0.0002444467,0.000368836,0.0002979261,0.0003665951,0.0002574454,0.0003075718,0.0002101446],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005101602,"about_ca_system_score_gemma":0.0002563469,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003942323,"about_ca_topic_score_gemma":0.003583364,"domain_scores_codex":[0.9997918,0.00005594359,0.00002785715,0.0000615619,0.00003701276,0.00002577402],"domain_scores_gemma":[0.9989538,0.0003177861,0.0003734378,0.0000479572,0.000122311,0.0001846222],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.00083889,0.00004577575,0.9948316,0.000009014983,0.00003970332,0.0004687593,0.00009635341,0.00008059756,0.00141448,0.000008400292,0.00005244248,0.002114034],"study_design_scores_gemma":[0.00001286619,0.0001473297,0.9982735,0.000005814843,0.00002727207,0.0007788798,0.00006925832,0.0003207794,0.0002715688,0.00004020688,0.00004877269,0.000003753554],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9996432,0.0001732729,0.00002327799,0.00001259213,0.000001506077,0.000001304183,0.00006567201,0.000002600737,0.00007658537],"genre_scores_gemma":[0.9997694,0.00003469576,0.00004456532,0.000006288497,0.000002468887,0.00000184657,0.00008503546,6.613372e-7,0.00005512148],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003942323,"threshold_uncertainty_score":0.007838726,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05963176644702149,"score_gpt":0.350913751466642,"score_spread":0.2912819850196205,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}