{"id":"W4210712271","doi":"10.3390/biomedicines10020322","title":"TSC/mTOR Pathway Mutation Associated Eosinophilic/Oncocytic Renal Neoplasms: A Heterogeneous Group of Tumors with Distinct Morphology, Immunohistochemical Profile, and Similar Genetic Background","year":2022,"lang":"en","type":"review","venue":"Biomedicines","topic":"Renal cell carcinoma treatment","field":"Medicine","cited_by":26,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia; Royal Columbian Hospital","funders":"Ministerstvo Zdravotnictví Ceské Republiky; Univerzita Karlova v Praze","keywords":"Eosinophilic; Pathology; Immunohistochemistry; Biology; TFE3; Renal oncocytoma; Oncocytoma; Renal cell carcinoma; Chromophobe cell; Clear cell; Medicine; Genetics; Gene; Gene expression","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002248805,0.0004616719,0.0009326898,0.002318371,0.0002133734,0.0005105311,0.0003542516,0.0004350672,0.001293571],"category_scores_gemma":[0.0003458475,0.0001312131,0.0003271146,0.001786998,0.0002527059,0.0005362549,0.000292495,0.0006949939,0.0005471188],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003215426,"about_ca_system_score_gemma":0.0007283652,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00069081,"about_ca_topic_score_gemma":0.001677687,"domain_scores_codex":[0.9998968,0.00001364224,0.00002151402,0.00001964238,0.00003732067,0.00001112405],"domain_scores_gemma":[0.9998498,0.00006428348,0.00002896005,0.000004118364,0.00003990363,0.00001286337],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00005874998,0.00003960827,0.000740281,0.01644774,0.000149516,0.001211564,0.00006611544,0.000248234,0.003937821,0.001150938,0.01511306,0.9608364],"study_design_scores_gemma":[0.00002362344,0.0001327657,0.005248258,0.00564636,0.0004892416,0.02688843,0.0001354432,0.0001658299,0.001860697,0.001280725,0.9580984,0.00003028212],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0004643104,0.997979,0.0001447594,0.0001876117,0.00009998422,0.000004510251,0.00002272262,0.000008027275,0.001089187],"genre_scores_gemma":[0.002159004,0.9969023,0.0002426471,0.0001647275,0.0001104063,0.000004672054,0.000055204,0.000001461634,0.0003596766],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.002318371,"threshold_uncertainty_score":0.004327416,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03761504606480013,"score_gpt":0.2874043419482982,"score_spread":0.249789295883498,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}