{"id":"W4210712271","doi":"10.3390/biomedicines10020322","title":"TSC/mTOR Pathway Mutation Associated Eosinophilic/Oncocytic Renal Neoplasms: A Heterogeneous Group of Tumors with Distinct Morphology, Immunohistochemical Profile, and Similar Genetic Background","year":2022,"lang":"en","type":"review","venue":"Biomedicines","topic":"Renal cell carcinoma treatment","field":"Medicine","cited_by":26,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia; Royal Columbian Hospital","funders":"Ministerstvo Zdravotnictví Ceské Republiky; Univerzita Karlova v Praze","keywords":"Eosinophilic; Pathology; Immunohistochemistry; Biology; TFE3; Renal oncocytoma; Oncocytoma; Renal cell carcinoma; Chromophobe cell; Clear cell; Medicine; Genetics; Gene; Gene expression","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0003099218,0.0009139646,0.003194028,0.0005667069,0.0001395789,0.00001804802,0.0002430336,0.0004021786,0.0002733584],"category_scores_gemma":[0.000173351,0.0006211094,0.0004106659,0.0008334725,0.0008436634,0.00003877368,0.0001708572,0.0005311863,0.00001028901],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001102871,"about_ca_system_score_gemma":0.0007011734,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002234577,"about_ca_topic_score_gemma":0.00001468772,"domain_scores_codex":[0.9959202,0.0003372733,0.001345169,0.0009978393,0.0008552815,0.0005442015],"domain_scores_gemma":[0.9971901,0.0005059264,0.001137779,0.0007009399,0.0001413842,0.0003238337],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.002712778,0.00357759,0.001807804,0.08258363,0.008502057,0.03565394,0.0009372996,0.00000348108,0.011539,0.00001494122,0.001372763,0.8512947],"study_design_scores_gemma":[0.03068124,0.06482511,0.0206787,0.1044076,0.05494492,0.1309497,0.0008732051,0.0002603098,0.001933206,0.00008803684,0.5845547,0.005803334],"study_design_candidate":"design_other","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.2172923,0.7797994,0.00001122524,0.00003603565,0.0001799814,0.002213968,0.0002922013,0.00007643981,0.00009843552],"genre_scores_gemma":[0.0542214,0.9361795,0.001133705,0.00008597875,0.0003809131,0.001329893,0.005960191,0.0003077393,0.0004006396],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.8454914,"threshold_uncertainty_score":0.999624,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03761504606480013,"score_gpt":0.2874043419482982,"score_spread":0.249789295883498,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}