{"id":"W4210712723","doi":"10.1161/circresaha.121.319100","title":"Noncanonical HIPPO/MST Signaling via BUB3 and FOXO Drives Pulmonary Vascular Cell Growth and Survival","year":2022,"lang":"en","type":"article","venue":"Circulation Research","topic":"Pulmonary Hypertension Research and Treatments","field":"Medicine","cited_by":51,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval","funders":"National Institute of General Medical Sciences; National Heart, Lung, and Blood Institute","keywords":"Pulmonary hypertension; Downregulation and upregulation; Hippo signaling pathway; Vascular smooth muscle; Hypoxia (environmental); Cancer research; Medicine; Pulmonary artery; Vascular remodelling in the embryo; Signal transduction; Biology; Cell biology; Internal medicine; Chemistry; Smooth muscle; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001300243,0.0001512748,0.0002875287,0.0003967912,0.0008798849,0.00005916518,0.0001163142,0.00007645311,0.0004510585],"category_scores_gemma":[0.0001796909,0.0001411742,0.00007946676,0.0005578693,0.0002520566,0.0001332808,0.0004207875,0.000704554,0.00002386321],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001131522,"about_ca_system_score_gemma":0.0002305251,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002823761,"about_ca_topic_score_gemma":0.000002967651,"domain_scores_codex":[0.9965227,0.0005647389,0.000239333,0.0005621107,0.001554013,0.000557079],"domain_scores_gemma":[0.9985345,0.0003871794,0.00003592333,0.0003029954,0.0002563635,0.0004830486],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0005557743,0.001223492,0.7373655,0.0003677229,0.000219301,0.004493313,0.0002143254,0.0001256232,0.2475359,0.0004148342,0.0002704659,0.007213686],"study_design_scores_gemma":[0.003581224,0.0008480147,0.9592842,0.00005053893,0.00008386449,0.0007432704,0.0008825858,0.0291464,0.001338445,0.002393899,0.001339203,0.0003083883],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9917052,0.003450973,0.0001611741,0.001173719,0.00005088156,0.0007079335,0.00001610088,0.00004092437,0.002693036],"genre_scores_gemma":[0.9987597,0.0003786267,0.0001815358,0.00008330285,0.00009349301,0.0001147654,0.0001280483,0.00003366426,0.000226895],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2461974,"threshold_uncertainty_score":0.6767452,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05468560920358109,"score_gpt":0.3325156175714634,"score_spread":0.2778300083678823,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}