{"id":"W4210717978","doi":"10.1002/advs.202104317","title":"<i>Cdyl</i> Deficiency Brakes Neuronal Excitability and Nociception through Promoting <i>Kcnb1</i> Transcription in Peripheral Sensory Neurons","year":2022,"lang":"en","type":"article","venue":"Advanced Science","topic":"Pain Mechanisms and Treatments","field":"Medicine","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"Structural Genomics Consortium; University of Toronto","funders":"National Cancer Institute; National Institute on Drug Abuse; National Natural Science Foundation of China","keywords":"Epigenetics; Neuropathic pain; Nociception; Chromodomain; Neuroscience; Gene knockdown; Nociceptor; Sensory system; Transcription factor; Gene silencing; Histone; Biology; Cell biology; Genetics; Receptor; RNA; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005496616,0.0001377688,0.0001678293,0.00007756813,0.0006073583,0.00002529015,0.0001154769,0.00001904267,0.00004248449],"category_scores_gemma":[0.00009899455,0.0001324567,0.00004013422,0.0006487747,0.0002956404,0.0005997752,0.00006787419,0.0002490553,0.000001609823],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002088232,"about_ca_system_score_gemma":0.0001231312,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000317142,"about_ca_topic_score_gemma":0.00001977635,"domain_scores_codex":[0.9981627,0.00009421509,0.0002170556,0.0006089934,0.0005258386,0.0003912359],"domain_scores_gemma":[0.9995488,0.00003742109,0.00006298572,0.0002156873,0.00004310157,0.00009204092],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0000908042,0.0003454597,0.01531487,0.00003284323,0.000001369152,0.00003477676,0.002659953,0.0004125358,0.9647901,0.0008301972,0.000001075329,0.01548598],"study_design_scores_gemma":[0.007361105,0.003698392,0.9176668,0.0001031847,0.0000714625,0.0006720171,0.005308013,0.01464098,0.03740157,0.01061325,0.001721104,0.0007421086],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9967932,0.0002282707,0.0008507846,0.0005533323,0.0002121584,0.0004833798,0.0000111937,0.0000588589,0.0008088526],"genre_scores_gemma":[0.9946628,0.00003946946,0.004349602,0.0007623581,0.00001471338,0.00006998395,0.000005261094,0.00001109234,0.00008472802],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.9273885,"threshold_uncertainty_score":0.5401427,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0201032141310226,"score_gpt":0.2825112065417114,"score_spread":0.2624079924106888,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}