{"id":"W4210717978","doi":"10.1002/advs.202104317","title":"<i>Cdyl</i> Deficiency Brakes Neuronal Excitability and Nociception through Promoting <i>Kcnb1</i> Transcription in Peripheral Sensory Neurons","year":2022,"lang":"en","type":"article","venue":"Advanced Science","topic":"Pain Mechanisms and Treatments","field":"Medicine","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"Structural Genomics Consortium; University of Toronto","funders":"National Cancer Institute; National Institute on Drug Abuse; National Natural Science Foundation of China","keywords":"Epigenetics; Neuropathic pain; Nociception; Chromodomain; Neuroscience; Gene knockdown; Nociceptor; Sensory system; Transcription factor; Gene silencing; Histone; Biology; Cell biology; Genetics; Receptor; RNA; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001192876,0.0003217981,0.0002531262,0.0002120036,0.0001853165,0.0002338355,0.0002186566,0.0003136676,0.003346553],"category_scores_gemma":[0.0001055832,0.0001529227,0.0002681508,0.0001063361,0.0004737412,0.0002316816,0.00031398,0.000648513,0.0004994008],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002796846,"about_ca_system_score_gemma":0.0002142729,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00061797,"about_ca_topic_score_gemma":0.001082903,"domain_scores_codex":[0.9998604,0.00001650214,0.00001698454,0.00003684164,0.0000297407,0.00003950025],"domain_scores_gemma":[0.9998336,0.00001429161,0.00006899762,0.00001491575,0.00001255093,0.00005566498],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001084684,0.000008110695,0.0001401164,0.00002282711,0.000003183296,0.00004192438,0.000003711414,0.00001883395,0.9991776,0.00006664939,0.00003672124,0.0003716633],"study_design_scores_gemma":[0.00004682048,0.0002064989,0.008339465,0.00001175162,0.00002072829,0.0006788558,0.00004522051,0.0007727086,0.9871071,0.000107136,0.002656064,0.000007642286],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9912528,0.0009015733,0.004903384,0.0002653089,0.00007896611,0.00002172834,0.000759681,0.000238841,0.001577782],"genre_scores_gemma":[0.9951634,0.0003360831,0.001390314,0.0000936916,0.00001146692,0.00002026455,0.0003432421,0.00005965308,0.002581844],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003346553,"threshold_uncertainty_score":0.01119536,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0201032141310226,"score_gpt":0.2825112065417114,"score_spread":0.2624079924106888,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}