{"id":"W4210719105","doi":"10.1093/nar/gkac090","title":"Rational design of small-molecules to recognize G-quadruplexes of c-MYC promoter and telomere and the evaluation of their <i>in vivo</i> antitumor activity against breast cancer","year":2022,"lang":"en","type":"article","venue":"Nucleic Acids Research","topic":"DNA and Nucleic Acid Chemistry","field":"Biochemistry, Genetics and Molecular Biology","cited_by":65,"is_retracted":false,"has_abstract":true,"ca_institutions":"Lakehead University; Thunder Bay Regional Research Institute","funders":"Health and Medical Research Fund; Department of Education of Guangdong Province; Natural Science Foundation of Guangdong Province; National Natural Science Foundation of China","keywords":"Biology; G-quadruplex; Telomere; Small molecule; DNA; Binding site; Nucleic acid; Biochemistry; Cancer cell; In vivo; Transfection; Cell biology; Molecular biology; Gene; Cancer; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00253337,0.0001023704,0.0002009615,0.00007689119,0.0001029062,0.00001044363,0.0002200905,0.00006164866,0.00009218917],"category_scores_gemma":[0.0001684092,0.00007856574,0.00003911972,0.0002319516,0.0004183348,0.000006448251,0.000374685,0.0001670179,1.480691e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002830542,"about_ca_system_score_gemma":0.0002541181,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00008546236,"about_ca_topic_score_gemma":0.00002205811,"domain_scores_codex":[0.998247,0.0005576086,0.000216979,0.0002830552,0.0005090458,0.0001862633],"domain_scores_gemma":[0.9991579,0.00009226509,0.00009806244,0.0002467307,0.0003574817,0.00004753398],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001096763,0.0001110784,0.002561007,0.00007684821,0.00004570695,5.461608e-7,0.0003339535,0.000310094,0.977833,0.00002321325,0.0002190181,0.01738876],"study_design_scores_gemma":[0.001656292,0.0002069895,0.01079434,0.00004290751,0.00001729775,0.00001148035,0.0006013009,0.003901098,0.9822865,0.0001836717,0.0001949532,0.0001031934],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9976505,0.0004962985,0.00009009639,0.0005727768,0.00001685102,0.000562594,0.0001997745,0.000001844323,0.0004092775],"genre_scores_gemma":[0.9990539,0.0002538466,0.0004074046,0.00003640589,0.00002900025,0.00013334,0.000009995772,0.00001491297,0.00006121862],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01728557,"threshold_uncertainty_score":0.3203818,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04935965356118436,"score_gpt":0.3275424819838864,"score_spread":0.278182828422702,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}