{"id":"W4210719105","doi":"10.1093/nar/gkac090","title":"Rational design of small-molecules to recognize G-quadruplexes of c-MYC promoter and telomere and the evaluation of their <i>in vivo</i> antitumor activity against breast cancer","year":2022,"lang":"en","type":"article","venue":"Nucleic Acids Research","topic":"DNA and Nucleic Acid Chemistry","field":"Biochemistry, Genetics and Molecular Biology","cited_by":65,"is_retracted":false,"has_abstract":true,"ca_institutions":"Lakehead University; Thunder Bay Regional Research Institute","funders":"Health and Medical Research Fund; Department of Education of Guangdong Province; Natural Science Foundation of Guangdong Province; National Natural Science Foundation of China","keywords":"Biology; G-quadruplex; Telomere; Small molecule; DNA; Binding site; Nucleic acid; Biochemistry; Cancer cell; In vivo; Transfection; Cell biology; Molecular biology; Gene; Cancer; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001549422,0.0003435519,0.0002691975,0.0001521818,0.0001076024,0.0001843706,0.0003126674,0.0002569462,0.0007708807],"category_scores_gemma":[0.0001544522,0.0001528014,0.0001669701,0.0001220507,0.0001385837,0.000200495,0.0001407369,0.0003295238,0.0003251056],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000359608,"about_ca_system_score_gemma":0.0003208631,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002774463,"about_ca_topic_score_gemma":0.0008002338,"domain_scores_codex":[0.9999498,0.0000122205,0.000004324821,0.00001001409,0.00001183772,0.00001180959],"domain_scores_gemma":[0.9999504,0.000009517049,0.00001742997,0.00000307831,0.00000674385,0.0000127955],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001722928,0.00009916101,0.000110562,0.0001579977,0.00001205363,0.00007719361,0.00002091516,0.002287135,0.9905139,0.0007944339,0.0001363177,0.005618009],"study_design_scores_gemma":[0.0001497669,0.001272309,0.000369551,0.0000113271,0.00002297974,0.0001041621,0.00001633768,0.004860624,0.9872317,0.0001258387,0.005821786,0.0000137176],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.971738,0.002398179,0.02196647,0.0001803313,0.00003141351,0.000402135,0.0003044349,0.0001957565,0.002783285],"genre_scores_gemma":[0.9617001,0.002187642,0.0321021,0.0001241704,0.00001084043,0.0003901567,0.0005320007,0.00004055352,0.00291235],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007708807,"threshold_uncertainty_score":0.002609134,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04935965356118436,"score_gpt":0.3275424819838864,"score_spread":0.278182828422702,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}