{"id":"W4210729266","doi":"10.1101/2022.01.27.477976","title":"The antimicrobial peptide cathelicidin is critical for the development of Th17 responses in severe inflammatory disease","year":2022,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Antimicrobial Peptides and Activities","field":"Immunology and Microbiology","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Institute of Genetics; Medical Research Council; University of Edinburgh","keywords":"Cathelicidin; Experimental autoimmune encephalomyelitis; Immunology; Multiple sclerosis; Autoimmunity; Inflammation; Microglia; Cytokine; Antimicrobial peptides; T cell; Biology; Medicine; Immune system; Innate immune system; Antimicrobial; Microbiology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002182577,0.0002570682,0.0002457551,0.0002359909,0.0002320926,0.0004405273,0.00008025704,0.0003829627,0.003544383],"category_scores_gemma":[0.0002699876,0.0001217283,0.000152923,0.0001242067,0.000202494,0.000193463,0.0003638288,0.0005726077,0.001488095],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001693449,"about_ca_system_score_gemma":0.0001821878,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001515099,"about_ca_topic_score_gemma":0.0001392541,"domain_scores_codex":[0.9998556,0.00002541565,0.000009401998,0.00002301385,0.00005279038,0.00003374668],"domain_scores_gemma":[0.9998428,0.00001490187,0.00003929175,0.00002275572,0.0000254631,0.00005470488],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0003210957,0.00002406813,0.001217112,0.00007581218,0.000007663749,0.0004240971,0.00002405785,0.0001172198,0.9897906,0.0007007329,0.0008836826,0.006413992],"study_design_scores_gemma":[0.00007678805,0.0002943182,0.05408941,0.00007513096,0.00002681152,0.003259865,0.0001111896,0.002139321,0.9029244,0.002118493,0.03487075,0.00001359106],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9529055,0.01134862,0.01397692,0.001338969,0.0007721595,0.00005773212,0.001191137,0.0005768022,0.01783224],"genre_scores_gemma":[0.9864457,0.001258197,0.003096225,0.0001211202,0.0001235266,0.00001930172,0.0004961222,0.00007963477,0.008360134],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003544383,"threshold_uncertainty_score":0.01185715,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01738569282022446,"score_gpt":0.2448264558234348,"score_spread":0.2274407630032103,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}