{"id":"W4210730907","doi":"10.1093/rheumatology/keac015","title":"Lymphocyte subset abnormalities in early severe scleroderma favor a Th2 phenotype and are not altered by prior immunosuppressive therapy","year":2022,"lang":"en","type":"article","venue":"Lara D. Veeken","topic":"Systemic Sclerosis and Related Diseases","field":"Medicine","cited_by":10,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"National Institute of Allergy and Infectious Diseases; National Institutes of Health","keywords":"Medicine; Phenotype; Scleroderma (fungus); Immunology; Lymphocyte subsets; Systemic scleroderma; Lymphocyte; Pathology; Immune system; Dermatomyositis; T cell; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007389491,0.0003401125,0.000587499,0.0002939908,0.0002039025,0.0002616791,0.0001214483,0.0002431425,0.001513175],"category_scores_gemma":[0.0005565815,0.00008227561,0.0002199431,0.0002464997,0.0002335735,0.0001698097,0.0001436936,0.0003182088,0.0001543866],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001311085,"about_ca_system_score_gemma":0.0001594152,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002188795,"about_ca_topic_score_gemma":0.0004600877,"domain_scores_codex":[0.9996477,0.0001614327,0.00004266639,0.00005393949,0.00004757157,0.0000466402],"domain_scores_gemma":[0.9995552,0.0001475845,0.0001652509,0.00003042035,0.00003883756,0.00006273162],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0311384,0.0007437526,0.8594862,0.0002853819,0.000416437,0.0006103604,0.0002141303,0.0004207532,0.06603682,0.00003946566,0.0002416302,0.0403667],"study_design_scores_gemma":[0.0008417772,0.01042872,0.9799861,0.0000341428,0.0002646242,0.001518263,0.00009157343,0.0003061999,0.005779974,0.00004695625,0.000695814,0.000005775174],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9991424,0.0004404023,0.00007406995,0.00001277476,0.000002336404,0.00001773603,0.00003507112,0.000003154673,0.0002720144],"genre_scores_gemma":[0.9996967,0.0000589093,0.00005312696,0.00001964037,0.000007912373,0.00001132206,0.00006808202,0.000001019699,0.00008334412],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001513175,"threshold_uncertainty_score":0.005062103,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01914801113531826,"score_gpt":0.2358727028281514,"score_spread":0.2167246916928331,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}