{"id":"W4210737894","doi":"10.1186/s13023-022-02172-5","title":"Development of a standard of care for patients with valosin-containing protein associated multisystem proteinopathy","year":2022,"lang":"en","type":"review","venue":"Orphanet Journal of Rare Diseases","topic":"Parkinson's Disease Mechanisms and Treatments","field":"Medicine","cited_by":36,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"Eunice Kennedy Shriver National Institute of Child Health and Human Development; National Center for Advancing Translational Sciences; National Institute of Arthritis and Musculoskeletal and Skin Diseases; National Institute on Aging; Medical Research Council; National Institute for Health and Care Research; National Institutes of Health; Motor Neurone Disease Association; University of Texas Southwestern Medical Center","keywords":"Medicine; Myopathy; Disease; Dementia; Intensive care medicine; Bioinformatics; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0002226479,0.0005031005,0.003199448,0.0003938482,0.0001295015,0.00001624754,0.0002298684,0.0001098012,0.0001198415],"category_scores_gemma":[0.000309654,0.0003431941,0.0008066715,0.0002758951,0.00003561321,0.00009063871,0.00006463985,0.0002022299,5.879959e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008921084,"about_ca_system_score_gemma":0.003643156,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000003020059,"about_ca_topic_score_gemma":0.000004403318,"domain_scores_codex":[0.9964709,0.0002095781,0.001475267,0.0003137671,0.001218464,0.0003120279],"domain_scores_gemma":[0.994603,0.000113408,0.003660357,0.0002622595,0.001020799,0.0003402117],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.01202584,0.003948805,0.006466425,0.1225652,0.007335125,0.0009400123,0.0009546026,0.000001863536,0.000005098476,0.00001378734,0.0000493123,0.8456939],"study_design_scores_gemma":[0.02249107,0.0218079,0.002203974,0.1693034,0.01963301,0.00009563223,0.001355049,0.000001316253,0.0001794481,0.000009510143,0.7621019,0.0008178121],"study_design_candidate":"design_other","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.04111077,0.9467887,0.00005283533,0.000001563519,0.0001126857,0.006267496,0.005635199,0.00001573844,0.00001500877],"genre_scores_gemma":[0.3095914,0.6512252,0.02388824,0.000023857,0.0002795413,0.003700132,0.01052013,0.0006301391,0.0001412721],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.8448761,"threshold_uncertainty_score":0.999902,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02410556985770698,"score_gpt":0.2879309813718119,"score_spread":0.263825411514105,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}