{"id":"W4210749812","doi":"10.3389/fnmol.2022.801757","title":"Metabotropic Glutamate Receptor 5 Antagonism Reduces Pathology and Differentially Improves Symptoms in Male and Female Heterozygous zQ175 Huntington’s Mice","year":2022,"lang":"en","type":"article","venue":"Frontiers in Molecular Neuroscience","topic":"Genetic Neurodegenerative Diseases","field":"Neuroscience","cited_by":18,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Ottawa","funders":"Canadian Institutes of Health Research; Krembil Foundation","keywords":"Neuropathology; Metabotropic glutamate receptor 5; Huntington's disease; Metabotropic glutamate receptor; Striatum; Neurodegeneration; Neuroscience; Medicine; Huntingtin; Internal medicine; Glutamate receptor; Endocrinology; Pharmacology; Disease; Biology; Receptor; Dopamine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0002165555,0.0003294171,0.0003917016,0.0004332828,0.0003803391,0.0001738568,0.0006524702,0.00005078597,0.00001478587],"category_scores_gemma":[0.0003967473,0.0003578193,0.00004982411,0.000679226,0.0007318329,0.0002140862,0.0008532791,0.0003943383,0.000001496273],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005293877,"about_ca_system_score_gemma":0.00007332971,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001770665,"about_ca_topic_score_gemma":0.000003106495,"domain_scores_codex":[0.9959382,0.0009406181,0.0004058087,0.0015348,0.000483659,0.000696925],"domain_scores_gemma":[0.9992232,0.00005781198,0.0001743679,0.0003669699,0.00001519579,0.0001624958],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005086603,0.0001440188,0.008665138,0.000017121,0.00000102682,0.0004895123,0.0002015671,0.0003375293,0.9884,0.00007360148,0.00003665929,0.001582964],"study_design_scores_gemma":[0.000801995,0.0004150022,0.02721643,0.000008205197,0.00001441591,0.0002076354,0.0001540638,0.002512472,0.967631,0.0002075,0.0004383211,0.0003929229],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9954263,0.0006347475,0.0007675097,0.0002243872,0.002239185,0.0005399463,0.00007711748,0.00004424496,0.00004659199],"genre_scores_gemma":[0.9964468,0.0002929123,0.001227998,0.001661786,0.00001779551,0.0001450831,0.000003735784,0.00004083732,0.000163],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02076895,"threshold_uncertainty_score":0.9998874,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008882655228220208,"score_gpt":0.2268071587266186,"score_spread":0.2179245034983984,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}