{"id":"W4210762547","doi":"10.3390/brainsci12020150","title":"Neurobiology of the Orexin System and Its Potential Role in the Regulation of Hedonic Tone","year":2022,"lang":"en","type":"review","venue":"Brain Sciences","topic":"Sleep and Wakefulness Research","field":"Neuroscience","cited_by":57,"is_retracted":false,"has_abstract":true,"ca_institutions":"NOSM University; Lakehead University; Adler; START Clinic; Professional Engineers Ontario; Queen's University","funders":"","keywords":"Orexin; Anhedonia; Lateral hypothalamus; Orexin-A; Neuroscience; Orexin receptor; Psychology; Mood; Neuropeptide; Internal medicine; Receptor; Pleasure; Medicine; Hypothalamus; Clinical psychology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001950414,0.0001770991,0.0002792583,0.0003417626,0.0002339943,0.0005216785,0.0002162612,0.0004494204,0.0011497],"category_scores_gemma":[0.0001232871,0.0001083045,0.0002319304,0.000212222,0.0005913224,0.000521224,0.0003563479,0.0005343948,0.0001156021],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004833565,"about_ca_system_score_gemma":0.0002671454,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009325072,"about_ca_topic_score_gemma":0.001316458,"domain_scores_codex":[0.9999428,0.00001314597,0.000004449267,0.00001362441,0.00001278566,0.00001329113],"domain_scores_gemma":[0.9999406,0.000008538393,0.00001880507,0.000003713653,0.0000104989,0.00001774417],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00149482,0.0003262122,0.01773189,0.002842315,0.0002724994,0.004375791,0.0004823293,0.0008345077,0.7176533,0.03050295,0.002237797,0.2212456],"study_design_scores_gemma":[0.0001746446,0.004257918,0.7069698,0.001024808,0.0003536173,0.01270434,0.001272607,0.002889797,0.09181143,0.04480762,0.1335301,0.0002034179],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"review","genre_scores_codex":[0.560293,0.4015877,0.01007127,0.003838575,0.0006321909,0.00007967826,0.0002509129,0.00006374212,0.02318296],"genre_scores_gemma":[0.8542811,0.1284062,0.004886462,0.0008009571,0.0002474241,0.00006490609,0.0001299446,0.000008337091,0.01117456],"genre_candidate":"review","genre_consensus":null,"teacher_disagreement_score":0.0011497,"threshold_uncertainty_score":0.003846169,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1121756733194578,"score_gpt":0.3771572653997806,"score_spread":0.2649815920803227,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}