{"id":"W4210773514","doi":"10.1002/syn.22224","title":"Endosomal recycling and dopamine neurotransmission: Exploring the links between the retromer and Parkinson's disease","year":2022,"lang":"en","type":"review","venue":"Synapse","topic":"Cellular transport and secretion","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Simon Fraser University","funders":"","keywords":"Retromer; Dopamine; Endosome; Neurotransmission; Dopamine transporter; Neuroscience; Dopamine Plasma Membrane Transport Proteins; Dopaminergic; Biology; Cell biology; Receptor; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003336575,0.000287817,0.0004028268,0.00003429024,0.0003600244,0.00004369449,0.0002463378,0.0001686513,0.00004765474],"category_scores_gemma":[0.00004683512,0.0001661472,0.0002199974,0.00009919918,0.0001322765,0.000004418085,0.0001434671,0.0006353011,0.000001080863],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000007848527,"about_ca_system_score_gemma":0.00006123225,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000006532092,"about_ca_topic_score_gemma":0.000002836868,"domain_scores_codex":[0.9986093,0.0002358342,0.0002905601,0.0004892732,0.0001586514,0.0002163626],"domain_scores_gemma":[0.9991963,0.00009174002,0.0001156261,0.0004545609,0.000009994022,0.0001317877],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00004681657,0.00001755962,0.001081227,0.002272879,0.0001874531,0.00006618511,0.00006339644,8.466412e-7,0.0004225418,0.00001820415,0.0000312005,0.9957917],"study_design_scores_gemma":[0.0001200407,0.00006696794,0.000833745,0.0003100614,0.0005312938,0.0000268663,0.00001699252,0.000002117495,0.00002355724,0.00000999751,0.9978547,0.000203694],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.02697233,0.9719796,0.00009830444,0.0001672608,0.0001660355,0.0004877151,0.00006326913,0.00001233463,0.00005310838],"genre_scores_gemma":[0.009159955,0.9879241,0.00001297464,0.00004642003,0.0005424408,0.0001870875,0.001920534,0.00004661702,0.0001598738],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9978235,"threshold_uncertainty_score":0.6775284,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05963273907079006,"score_gpt":0.2741832562638039,"score_spread":0.2145505171930138,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}