{"id":"W4210773546","doi":"10.1038/s41591-021-01655-5","title":"Intestinal Akkermansia muciniphila predicts clinical response to PD-1 blockade in patients with advanced non-small-cell lung cancer","year":2022,"lang":"en","type":"article","venue":"Nature Medicine","topic":"Gut microbiota and health","field":"Biochemistry, Genetics and Molecular Biology","cited_by":642,"is_retracted":false,"has_abstract":false,"ca_institutions":"Centre Hospitalier Universitaire de Sherbrooke; Centre Hospitalier de l’Université de Montréal","funders":"Canadian Institutes of Health Research; Labex Immuno-Oncology; National Institutes of Health; Da Volterra; Daiichi Sankyo Europe; National Cancer Institute; Servier; Fondation Gustave Roussy; Direction Générale de l’offre de Soins; Chancellerie des Universités de Paris; Institut Universitaire de France; Ligue Contre le Cancer; Ministero dell’Istruzione, dell’Università e della Ricerca; Horizon 2020 Framework Programme; Fondation pour la Recherche Médicale; Institut National de la Santé et de la Recherche Médicale; Institute of Cancer Research; Institut Du Cancer de Montréal; Agence Nationale de la Recherche; Fondation Leducq; Fondation ARC pour la Recherche sur le Cancer; E-Rare; Institut National Du Cancer; AstraZeneca; Novocure; Taiho Pharmaceutical; Celgene; Genentech; Institut Gustave-Roussy; Cancer Prevention and Research Institute of Texas; European Commission; Sanofi; GlaxoSmithKline; Seerave Foundation; Association pour la Recherche sur le Cancer; Relay Therapeutics; Amgen; Symphogen; Pfizer; Eli Lilly and Company; Samsung; Bristol-Myers Squibb","keywords":"Akkermansia muciniphila; Akkermansia; Biology; Internal medicine; Oncology; Gut flora; Gastroenterology; Cancer research; Immunology; Medicine; Bacteria; Bacteroides; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003818506,0.0003368077,0.0005249897,0.0004549011,0.0004037384,0.0007383442,0.0003161522,0.0005824455,0.001535368],"category_scores_gemma":[0.001830046,0.000217065,0.0004719536,0.000565415,0.0003291094,0.0005133885,0.0004132895,0.0009403371,0.0002717983],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000283532,"about_ca_system_score_gemma":0.0002016505,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009813495,"about_ca_topic_score_gemma":0.001778001,"domain_scores_codex":[0.9996912,0.00007914997,0.00004238153,0.00007200491,0.00004350209,0.00007163887],"domain_scores_gemma":[0.9990067,0.0002766109,0.0003560772,0.00005291161,0.00009918146,0.0002085817],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0006251375,0.00005431317,0.9947627,0.00002129961,0.00006483305,0.000162511,0.00002479716,0.00007598134,0.0008634276,0.00001629882,0.0001929904,0.003135893],"study_design_scores_gemma":[0.00002521343,0.0002692448,0.9973001,0.00001226622,0.00009436682,0.0008226222,0.0001628293,0.0005617714,0.0002187613,0.0000607845,0.000465365,0.00000671211],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9976699,0.0009412269,0.00007764503,0.0001623288,0.00003720965,0.000009710596,0.0002223585,0.000007766159,0.0008718401],"genre_scores_gemma":[0.9993,0.0001419934,0.00006236027,0.00004889707,0.00002934464,0.000005092699,0.0002164756,0.000001394627,0.0001944143],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001535368,"threshold_uncertainty_score":0.005136251,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005178728616585331,"score_gpt":0.3034241396291433,"score_spread":0.298245411012558,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}