{"id":"W4210799783","doi":"10.1016/j.bpj.2022.02.001","title":"A general mathematical model for the in vitro assembly dynamics of intermediate filament proteins","year":2022,"lang":"en","type":"article","venue":"Biophysical Journal","topic":"Skin and Cellular Biology Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":6,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Manitoba","funders":"Deutsche Forschungsgemeinschaft; Natural Sciences and Engineering Research Council of Canada; Burroughs Wellcome Fund","keywords":"Intermediate filament; Desmin; Vimentin; Protein filament; Persistence length; Microtubule; Biophysics; Kinetics; Treadmilling; Keratin; Cytoskeleton; Actin; Intermediate Filament Protein; Tubulin; Chemistry; Crystallography; Physics; Biology; Cell biology; Biochemistry; Polymer; Microfilament; Nuclear magnetic resonance","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009894624,0.001087878,0.001161963,0.0008930133,0.0009761582,0.001930934,0.002774733,0.003664375,0.004962907],"category_scores_gemma":[0.002639167,0.0008696702,0.001684554,0.0007897113,0.001456363,0.002947719,0.001204376,0.001803664,0.001311566],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.002424546,"about_ca_system_score_gemma":0.001486898,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.007870307,"about_ca_topic_score_gemma":0.003742255,"domain_scores_codex":[0.99967,0.000084712,0.00001815598,0.00008083221,0.0000806418,0.00006567271],"domain_scores_gemma":[0.9993575,0.0002965333,0.000121199,0.00005247583,0.000103412,0.00006894293],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"simulation_or_modeling","study_design_gemma":"simulation_or_modeling","study_design_scores_codex":[0.00002476877,0.00005640645,0.0003220784,0.00009749918,0.00003140283,0.0002640321,0.0001702644,0.5921667,0.01052379,0.3919887,0.001566511,0.002787879],"study_design_scores_gemma":[0.00001220808,0.00001355129,0.000118291,0.00000901603,0.000009390176,0.00005704494,0.00001364539,0.970385,0.0003899793,0.02765407,0.001322574,0.00001526961],"study_design_candidate":"simulation_or_modeling","study_design_consensus":"simulation_or_modeling","genre_codex":"methods","genre_gemma":"empirical","genre_scores_codex":[0.06210353,0.001443101,0.9011666,0.003123468,0.0002842831,0.0001307276,0.0005745741,0.0002852104,0.03088862],"genre_scores_gemma":[0.7970966,0.003338261,0.112685,0.001007373,0.0003321362,0.0009224571,0.0008294742,0.0003745078,0.08341427],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.007870307,"threshold_uncertainty_score":0.01759142,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01743066504267995,"score_gpt":0.2861847103078815,"score_spread":0.2687540452652015,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}