{"id":"W4210802691","doi":"10.1021/acsomega.1c05337","title":"Fluorocyclopropane-Containing Proline Analogue: Synthesis and Conformation of an Item in the Peptide Chemistʼs Toolbox","year":2022,"lang":"en","type":"article","venue":"ACS Omega","topic":"Fluorine in Organic Chemistry","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Centre in Green Chemistry and Catalysis","funders":"Région Normandie; Université de Rouen; Normandie Université; Agence Nationale de la Recherche; Association Instituts Carnot; Institut Universitaire de France; Centre National de la Recherche Scientifique","keywords":"Tripeptide; Proline; Ring (chemistry); Cyclopropane; Chemistry; Stereochemistry; Amino acid; Combinatorial chemistry; Organic chemistry; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009787039,0.0001862361,0.000137693,0.0001016354,0.000197414,0.0001568449,0.0002580765,0.0003257916,0.00238404],"category_scores_gemma":[0.0001162828,0.00008629516,0.0001218965,0.0001840417,0.0001317555,0.0002694149,0.0001571751,0.0005213721,0.0005364211],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001489776,"about_ca_system_score_gemma":0.0001987921,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003893631,"about_ca_topic_score_gemma":0.0004873505,"domain_scores_codex":[0.9999568,0.000004863442,0.000002658114,0.00001474475,0.000009615163,0.00001131968],"domain_scores_gemma":[0.9999553,0.000005864442,0.00001045448,0.00000626306,0.000007122933,0.0000149347],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003246389,0.00006137993,0.0002272519,0.0003403423,0.0000117819,0.0006811543,0.0000870246,0.001193734,0.9759186,0.002464701,0.0006458022,0.0180437],"study_design_scores_gemma":[0.0001184819,0.002062148,0.001721832,0.00006056213,0.00003693685,0.001365613,0.00005710196,0.002350064,0.942606,0.0005818881,0.04898779,0.00005166723],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9582549,0.005071176,0.02142199,0.0003475693,0.0001706473,0.0001290781,0.001065757,0.0001755974,0.0133632],"genre_scores_gemma":[0.9684835,0.00293607,0.02207863,0.0001237501,0.00003212196,0.00008144418,0.0004880552,0.00003712298,0.005739357],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00238404,"threshold_uncertainty_score":0.007975399,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05627208078367628,"score_gpt":0.36303404895251,"score_spread":0.3067619681688337,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}