{"id":"W4210804980","doi":"10.3410/f.7927957.8385062","title":"Faculty Opinions recommendation of Ribose 2'-O-methylation provides a molecular signature for the distinction of self and non-self mRNA dependent on the RNA sensor Mda5.","year":2011,"lang":"en","type":"dataset","venue":"Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature","topic":"RNA modifications and cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Universität Heidelberg; Medical Research Council; Deutsche Forschungsgemeinschaft; European Commission; Wellcome Trust; Institute of Genetics; National Institutes of Health; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung; Novartis Foundation; Austrian Science Fund; Imperial College London; National Science Foundation","keywords":"Messenger RNA; Signature (topology); Ribose; Methylation; RNA; RNA methylation; Computational biology; MDA5; Chemistry; Molecular biology; Biology; Biochemistry; Gene; Mathematics; Enzyme","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001013102,0.002130582,0.001363914,0.002897009,0.0006720552,0.002077818,0.002498506,0.002358823,0.03256651],"category_scores_gemma":[0.007285331,0.0005449574,0.001460406,0.004236583,0.0003373467,0.001040613,0.001155585,0.001767222,0.03734174],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001589527,"about_ca_system_score_gemma":0.00240188,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.02276818,"about_ca_topic_score_gemma":0.05131768,"domain_scores_codex":[0.9987833,0.0001970382,0.0001280336,0.0003446914,0.0003943112,0.0001527007],"domain_scores_gemma":[0.9972378,0.0009647568,0.0003603208,0.000494672,0.0006595516,0.0002828624],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0002708912,0.00005413511,0.003672365,0.00203508,0.0001311154,0.00005552321,0.00002164681,0.0007044895,0.0004842867,0.0004301479,0.9847834,0.007357048],"study_design_scores_gemma":[0.0004588395,0.00005896672,0.02181953,0.0005296299,0.0001859247,0.0001875734,0.00006893691,0.001635348,0.0019899,0.001196395,0.9718123,0.00005678951],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"dataset","genre_gemma":"dataset","genre_scores_codex":[0.0004328518,0.0002588957,0.00008770838,0.0001607502,0.0000354912,0.00001046418,0.9978219,0.0003224008,0.0008696531],"genre_scores_gemma":[0.001109042,0.0001522202,0.0003166267,0.00007078478,0.000008929574,0.00003697074,0.9973635,0.00003795049,0.0009039678],"genre_candidate":"dataset","genre_consensus":"dataset","teacher_disagreement_score":0.03256651,"threshold_uncertainty_score":0.1089458,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02363033835456221,"score_gpt":0.3175712710932174,"score_spread":0.2939409327386552,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}