{"id":"W4210804984","doi":"10.1093/ibd/izab361","title":"INSPECT: A Retrospective Study to Evaluate Long-term Effectiveness and Safety of Darvadstrocel in Patients With Perianal Fistulizing Crohn’s Disease Treated in the ADMIRE-CD Trial","year":2022,"lang":"en","type":"article","venue":"Inflammatory Bowel Diseases","topic":"Anorectal Disease Treatments and Outcomes","field":"Medicine","cited_by":57,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University","funders":"Janssen Pharmaceuticals; Takeda Pharmaceuticals International; Genentech; AOP Orphan; Kyowa Hakko Kirin; Mitsubishi Tanabe Pharma Corporation; Celltrion; Astellas Pharma; Mylan; Danone; Therakos; Teva Pharmaceutical Industries; Gilead Sciences; Celgene; BioClinica; Pfizer; Biogen; LivaNova; GlaxoSmithKline; IC Design Education Center; Bristol-Myers Squibb; Eli Lilly and Company; Seres Therapeutics; AstraZeneca; Tillotts Pharma; Amgen; Dr. Falk Pharma; Abbott Laboratories","keywords":"Medicine; Crohn's disease; Adverse effect; Retrospective cohort study; Internal medicine; Clinical trial; Randomized controlled trial; Surgery; Fistula; Disease; Gastroenterology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002933703,0.0002866706,0.001004399,0.0005856122,0.0004585869,0.0006848465,0.0003718065,0.0004304551,0.001685246],"category_scores_gemma":[0.004975537,0.000283258,0.0007547965,0.0008957834,0.000434932,0.0006296635,0.00037169,0.0005106357,0.0003330815],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005025338,"about_ca_system_score_gemma":0.0005530867,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005257103,"about_ca_topic_score_gemma":0.000674653,"domain_scores_codex":[0.9978003,0.0007672951,0.0004210509,0.0004340641,0.0004237641,0.0001534084],"domain_scores_gemma":[0.9923057,0.001682049,0.004340798,0.0006410375,0.0005339611,0.0004964168],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.01461293,0.0003740334,0.9743066,0.0002778009,0.0004419605,0.0003815783,0.0001912722,0.00009583928,0.0009943722,0.00007637463,0.0005523094,0.007694873],"study_design_scores_gemma":[0.003084632,0.01140355,0.9768519,0.0001047117,0.0007784257,0.002462286,0.0002417922,0.0004183868,0.0007614853,0.00007056286,0.00378602,0.00003635047],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9946961,0.002643755,0.0002982897,0.0000540961,0.00001579627,0.0003070929,0.001078705,0.000009501576,0.0008965524],"genre_scores_gemma":[0.9963271,0.0004402701,0.0003810211,0.0001580135,0.00005446025,0.0002672627,0.002141603,0.000007703905,0.0002225737],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002933703,"threshold_uncertainty_score":0.01551503,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01001308097234662,"score_gpt":0.2727509896852566,"score_spread":0.26273790871291,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}