{"id":"W4210804984","doi":"10.1093/ibd/izab361","title":"INSPECT: A Retrospective Study to Evaluate Long-term Effectiveness and Safety of Darvadstrocel in Patients With Perianal Fistulizing Crohn’s Disease Treated in the ADMIRE-CD Trial","year":2022,"lang":"en","type":"article","venue":"Inflammatory Bowel Diseases","topic":"Anorectal Disease Treatments and Outcomes","field":"Medicine","cited_by":57,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University","funders":"Janssen Pharmaceuticals; Takeda Pharmaceuticals International; Genentech; AOP Orphan; Kyowa Hakko Kirin; Mitsubishi Tanabe Pharma Corporation; Celltrion; Astellas Pharma; Mylan; Danone; Therakos; Teva Pharmaceutical Industries; Gilead Sciences; Celgene; BioClinica; Pfizer; Biogen; LivaNova; GlaxoSmithKline; IC Design Education Center; Bristol-Myers Squibb; Eli Lilly and Company; Seres Therapeutics; AstraZeneca; Tillotts Pharma; Amgen; Dr. Falk Pharma; Abbott Laboratories","keywords":"Medicine; Crohn's disease; Adverse effect; Retrospective cohort study; Internal medicine; Clinical trial; Randomized controlled trial; Surgery; Fistula; Disease; Gastroenterology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003054128,0.0003257714,0.0005553195,0.0002817778,0.0001845748,0.00003136707,0.00016743,0.00002161948,0.0002325895],"category_scores_gemma":[0.0002061755,0.0002200391,0.0001255432,0.0004251112,0.0001146496,0.0001368966,0.0001539458,0.0001837844,0.000002022521],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005045673,"about_ca_system_score_gemma":0.0002700498,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001066332,"about_ca_topic_score_gemma":0.0002505494,"domain_scores_codex":[0.9972063,0.0006678064,0.000450564,0.0005344942,0.000829545,0.000311291],"domain_scores_gemma":[0.998893,0.0001327707,0.0001473576,0.0004144188,0.00009895051,0.0003135632],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.2133738,0.004886288,0.778297,0.0001281161,0.0001820567,0.001604232,0.001175725,0.00005940576,0.000001839069,0.00001770293,0.00000716277,0.0002667004],"study_design_scores_gemma":[0.07221324,0.002844933,0.9230636,0.0001758024,0.0005866097,0.000001539684,0.0008713586,0.00001198129,0.000001219083,0.00001802531,0.000002133848,0.000209596],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9932603,0.0001909418,6.232353e-7,0.00004642056,0.00005352189,0.006032341,0.0003066365,0.00003528535,0.00007395403],"genre_scores_gemma":[0.9987044,0.000004996564,0.00000212843,0.000101637,0.00003332317,0.0009838226,0.0001175323,0.00003508837,0.00001706705],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1447666,"threshold_uncertainty_score":0.8972936,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01001308097234662,"score_gpt":0.2727509896852566,"score_spread":0.26273790871291,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}