{"id":"W4210805203","doi":"10.1128/mbio.02920-21","title":"Structure of the Core Postfusion Porcine Endogenous Retrovirus Fusion Protein","year":2022,"lang":"en","type":"article","venue":"mBio","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"National Institute of General Medical Sciences; Canadian Institutes of Health Research; Canada Research Chairs; Government of Canada; Canada Foundation for Innovation; U.S. Department of Energy","keywords":"Virology; Endogeny; Retrovirus; Fusion protein; Fusion; Core protein; Core (optical fiber); Endogenous retrovirus; Biology; Computational biology; Cell biology; Virus; Recombinant DNA; Computer science; Gene; Genetics; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001509752,0.0001055637,0.0001021968,0.00003271084,0.0002543993,0.000005537445,0.0004242309,0.00006831458,0.0005507888],"category_scores_gemma":[0.00003514792,0.00007843458,0.00008482968,0.0001826791,0.0000680705,0.000001010987,0.0005610945,0.0002002701,0.000002218904],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003096529,"about_ca_system_score_gemma":0.0001272998,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00006853876,"about_ca_topic_score_gemma":0.0001043949,"domain_scores_codex":[0.9989456,0.0001353025,0.0001458868,0.0002386392,0.0003347777,0.0001998157],"domain_scores_gemma":[0.999241,0.000003837651,0.00008947972,0.000565386,0.00006085767,0.00003945868],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001218368,0.00004820077,0.001023772,0.00001117281,0.00001660019,0.000004006901,0.00005664175,0.00006450435,0.9951809,0.0000121178,0.0006059962,0.001757714],"study_design_scores_gemma":[0.0005035123,0.002513549,0.0007891728,0.000004352006,0.000005327711,0.00002955646,0.00005042698,0.00001418938,0.9896585,0.0001050473,0.00623605,0.00009036468],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9979762,0.0007451155,0.000003389052,0.0002383176,0.0001074568,0.0004941212,0.0001603655,0.000007030203,0.0002679367],"genre_scores_gemma":[0.998329,0.00001818498,0.00003859621,0.0002559137,0.00008863939,0.00001795679,0.0001121303,0.00002210999,0.001117411],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005630054,"threshold_uncertainty_score":0.6030751,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0214446235946128,"score_gpt":0.258973182659967,"score_spread":0.2375285590653542,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}