{"id":"W4210812873","doi":"10.3410/f.12796960.14073058","title":"Faculty Opinions recommendation of Screening of OPTN in French familial amyotrophic lateral sclerosis.","year":2011,"lang":"en","type":"dataset","venue":"Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature","topic":"Amyotrophic Lateral Sclerosis Research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Montreal Neurological Institute and Hospital","funders":"","keywords":"Optineurin; Amyotrophic lateral sclerosis; Genetics; Nonsense mutation; Heterozygote advantage; Missense mutation; Exon; Coding region; Compound heterozygosity; Mutation; Gene; Biology; Medicine; Allele; Disease; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001492864,0.001192466,0.001029428,0.006267481,0.0004136603,0.001328907,0.00130029,0.00130412,0.04295523],"category_scores_gemma":[0.01097749,0.0002748123,0.0009980734,0.006353105,0.0001701968,0.0006419151,0.0008118632,0.0006135248,0.02110682],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001574829,"about_ca_system_score_gemma":0.003435116,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.03282947,"about_ca_topic_score_gemma":0.05029749,"domain_scores_codex":[0.9988471,0.0002271123,0.0002325631,0.0003039412,0.0002702314,0.000119073],"domain_scores_gemma":[0.994915,0.001311413,0.001168307,0.0005974529,0.001497835,0.000509932],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0003165751,0.0000446151,0.0226526,0.002328925,0.0003695973,0.0001169876,0.00004380645,0.0005011561,0.0003707143,0.0003447008,0.9549203,0.01799008],"study_design_scores_gemma":[0.0006945581,0.00006532966,0.1057676,0.0007688116,0.000341624,0.0003140481,0.0001148717,0.001320419,0.0008757508,0.0005449014,0.8891286,0.0000635595],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"dataset","genre_gemma":"dataset","genre_scores_codex":[0.0009905079,0.0002158859,0.00005677332,0.0001467306,0.00002204018,0.00002544045,0.9975305,0.0001525844,0.0008595944],"genre_scores_gemma":[0.002715074,0.0001452524,0.0003865187,0.00008044983,0.00001547033,0.00009539477,0.995894,0.00002671864,0.0006411527],"genre_candidate":"dataset","genre_consensus":"dataset","teacher_disagreement_score":0.04295523,"threshold_uncertainty_score":0.1436995,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08008813089107072,"score_gpt":0.3662986678189238,"score_spread":0.2862105369278531,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}