{"id":"W4210840207","doi":"10.1161/jaha.121.022070","title":"Myogenic Vasoconstriction Requires Canonical G <sub>q/11</sub> Signaling of the Angiotensin II Type 1 Receptor","year":2022,"lang":"en","type":"article","venue":"Journal of the American Heart Association","topic":"Receptor Mechanisms and Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":24,"is_retracted":false,"has_abstract":true,"ca_institutions":"Robarts Clinical Trials; Western University","funders":"","keywords":"Myogenic contraction; Angiotensin II; Gq alpha subunit; Vasoconstriction; Endocrinology; Internal medicine; Mesenteric arteries; Vascular smooth muscle; Receptor; Cell biology; Transient receptor potential channel; Medicine; Signal transduction; Biology; G protein-coupled receptor; Artery; Smooth muscle","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008328324,0.0002311502,0.0001299998,0.00009381279,0.0001001207,0.0001699276,0.0001505053,0.0001561289,0.001483419],"category_scores_gemma":[0.00006975426,0.0001519506,0.0001410605,0.0000476937,0.0002399901,0.0001119958,0.0001476753,0.0004821902,0.0004776246],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002201775,"about_ca_system_score_gemma":0.0001263591,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004322224,"about_ca_topic_score_gemma":0.000830034,"domain_scores_codex":[0.9999169,0.00001288312,0.000006821451,0.00002011352,0.00001583765,0.00002747834],"domain_scores_gemma":[0.9999056,0.00001125923,0.00003773325,0.00000904984,0.000006239618,0.00003007157],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008478426,0.000009571444,0.0001387159,0.00001179147,0.000001318832,0.00002852,0.000003905104,0.00001788028,0.9991707,0.0001350312,0.00003393252,0.0003639143],"study_design_scores_gemma":[0.00006222101,0.000527121,0.02526518,0.00001176004,0.00002048836,0.0004428174,0.00004378129,0.001038033,0.9685592,0.0001635292,0.003859956,0.00000601616],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9947594,0.0005276421,0.001953011,0.0001490658,0.00002600338,0.00002118088,0.0003533872,0.0000793452,0.002131057],"genre_scores_gemma":[0.9950997,0.0005795354,0.001339013,0.0001159273,0.00001537511,0.00003858672,0.0003432211,0.00002781158,0.00244086],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001483419,"threshold_uncertainty_score":0.004962504,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008598313817043884,"score_gpt":0.2325810174965433,"score_spread":0.2239827036794994,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}