{"id":"W4210847184","doi":"10.3390/biomedicines10020393","title":"Involvement of Oxidative Stress in the Development of Subcellular Defects and Heart Disease","year":2022,"lang":"en","type":"review","venue":"Biomedicines","topic":"Cardiac electrophysiology and arrhythmias","field":"Medicine","cited_by":52,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba; St. Boniface Hospital","funders":"Vedecká Grantová Agentúra MŠVVaŠ SR a SAV; Agentúra na Podporu Výskumu a Vývoja; Ministerstvo školstva, vedy, výskumu a športu Slovenskej republiky","keywords":"Oxidative stress; Endoplasmic reticulum; Sarcolemma; Cell biology; NADPH oxidase; Oxidative phosphorylation; Ryanodine receptor; Mitochondrion; Chemistry; Myofibril; Intracellular; Biochemistry; Biology; Myocyte","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005384014,0.0004346042,0.0004891413,0.00149745,0.0003509813,0.000523266,0.0003898782,0.0007246362,0.001693013],"category_scores_gemma":[0.0003635627,0.0001447621,0.000345741,0.0005458515,0.0003918813,0.0004670176,0.0007096343,0.0005928845,0.0002685878],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002601001,"about_ca_system_score_gemma":0.0002956988,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004481695,"about_ca_topic_score_gemma":0.0003135994,"domain_scores_codex":[0.9996785,0.00008215306,0.00004361502,0.0000704128,0.00007011434,0.00005522544],"domain_scores_gemma":[0.9996445,0.00005785034,0.0001349685,0.00002257145,0.00007225633,0.00006787918],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.004031775,0.001174176,0.1960261,0.009742455,0.001147618,0.02511387,0.001925439,0.0008388804,0.3635403,0.01980353,0.00533442,0.3713215],"study_design_scores_gemma":[0.0001642044,0.003757247,0.7073398,0.001677465,0.001158584,0.03882568,0.001606056,0.001705681,0.07289635,0.02814965,0.1425648,0.0001544057],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.3027044,0.6703835,0.008077319,0.00193873,0.000706716,0.0001458006,0.0005156777,0.0001435937,0.01538441],"genre_scores_gemma":[0.8057522,0.1851654,0.00278824,0.0003792597,0.0007070971,0.00006631235,0.0003481199,0.0000136531,0.004779682],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.001693013,"threshold_uncertainty_score":0.005663693,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04247288621264424,"score_gpt":0.3157042378691537,"score_spread":0.2732313516565095,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}